| dc.creator | Martin, Luiz Fernando | |
| dc.creator | Rocha, Eduardo | |
| dc.creator | Garcia, Sergio Britto | |
| dc.creator | Paula, Jayter Silva de | |
| dc.date.accessioned | 2013-12-11T12:57:50Z | |
| dc.date.accessioned | 2018-07-04T16:41:38Z | |
| dc.date.available | 2013-12-11T12:57:50Z | |
| dc.date.available | 2018-07-04T16:41:38Z | |
| dc.date.created | 2013-12-11T12:57:50Z | |
| dc.date.issued | 2013 | |
| dc.identifier | 1472-6882 | |
| dc.identifier | http://www.producao.usp.br/handle/BDPI/43609 | |
| dc.identifier | 10.1186/1472-6882-13-337 | |
| dc.identifier | http://www.biomedcentral.com/1472-6882/13/337 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1639069 | |
| dc.description.abstract | Abstract
Background
The objective of this study was to investigate the effects of the Brazilian Scaptotrigona sp propolis, a widely used folk medicine, in corneal wound healing and inflammation.
Methods
Corneal epithelial defects of 1 mm in diameter were made in the right eyes of Wistar male adult rats by cauterization with silver nitrate sticks. Subsequently, they were divided in two groups (n = 40 rats/group): Brazilian propolis (BP) group was topically treated with a microemulsion containing 1% Brazilian propolis; vehicle (VH) group received the same formulation without propolis. The epithelial defect area was photographed and measured at t = 0 (wound induction), and after 12, 24, 48 and 120 h of treatment. The inflammatory response was evaluated based on counting of neutrophils. Epithelial regeneration rates were determined based on Ki-67 expression in basal epithelial cells. Comparisons were made using the Kruskal-Wallis and the Mann–Whitney U test.
Results
The BP group presented both smaller epithelial defect areas at 12, 24 and 48 h and fewer corneal infiltrating neutrophils at 24 and 48 h (P < 0.01) than the VH group. These effects were associated with more pervasive Ki-67 staining in the BP group at 12 and 24 h (P < 0.05).
Conclusions
Topically applied BP accelerated wound healing and reduced the inflammatory response to silver nitrate-induced corneal alkali burns in rats. | |
| dc.language | eng | |
| dc.relation | BMC Complementary and Alternative Medicine | |
| dc.rights | Martin et al.; licensee BioMed Central Ltd. - This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| dc.rights | openAccess | |
| dc.title | Topical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns | |
| dc.type | Artículos de revistas | |
