dc.creator | Denny, Carina | |
dc.creator | Melo, Priscilla S | |
dc.creator | Franchin, Marcelo | |
dc.creator | Massarioli, Adna P | |
dc.creator | Bergamaschi, Keityane B | |
dc.creator | Alencar, Severino M de | |
dc.creator | Rosalen, Pedro L | |
dc.date.accessioned | 2013-12-11T12:57:48Z | |
dc.date.accessioned | 2018-07-04T16:41:38Z | |
dc.date.available | 2013-12-11T12:57:48Z | |
dc.date.available | 2018-07-04T16:41:38Z | |
dc.date.created | 2013-12-11T12:57:48Z | |
dc.date.issued | 2013 | |
dc.identifier | BMC Complementary and Alternative Medicine, v.13, 2013 | |
dc.identifier | 1472-6882 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/43608 | |
dc.identifier | 10.1186/1472-6882-13-235 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1639068 | |
dc.description.abstract | Abstract
Background
Guava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE).
Methods
The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS.
Results
GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 ± 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis.
Conclusions
The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances. | |
dc.language | eng | |
dc.publisher | BioMed Central | |
dc.relation | BMC Complementary and Alternative Medicine | |
dc.rights | Denny et al.; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights | openAccess | |
dc.subject | Agro-industrial residue | |
dc.subject | Anti-inflammatory | |
dc.subject | Antinociceptive | |
dc.subject | Quercetin | |
dc.subject | Epicatechin | |
dc.subject | Guava pomace | |
dc.title | Guava pomace: a new source of anti-inflammatory and analgesic bioactives | |
dc.type | Artículos de revistas | |