Níveis diferentes de MT-I/II entre pacientes com MTLE com ou sem crise generalizada: os níveis hipocampais de MT-I/II afetam o alastramento das crises, ou o alastramento das crises promove expressão diferencial de MT-I/II?

dc.creatorPeixoto-Santos, José Eduardo
dc.creatorGalvis-Alonso, Orfa Yineth
dc.creatorVelasco, Tonicarlo R.
dc.creatorKandratavicius, Ludmyla
dc.creatorAssirati Jr, João Alberto
dc.creatorCarlotti, Carlos Gilberto
dc.creatorScandiuzzi, Renata Caldo
dc.creatorSerafini, Luciano Neder
dc.creatorLeite, João Pereira
dc.date.accessioned2013-11-04T12:53:14Z
dc.date.accessioned2018-07-04T16:38:28Z
dc.date.available2013-11-04T12:53:14Z
dc.date.available2018-07-04T16:38:28Z
dc.date.created2013-11-04T12:53:14Z
dc.date.issued2012
dc.identifierJ. epilepsy clin. neurophysiol.,v.18,n.1,p.16-20,2012
dc.identifier1676-2649
dc.identifierhttp://www.producao.usp.br/handle/BDPI/40112
dc.identifier10.1590/S1676-26492012000100005
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_pdf&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1638345
dc.description.abstractIn the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns.
dc.languageeng
dc.publisherLiga Brasileira de Epilepsia (LBE)
dc.relationJournal of Epilepsy and Clinical Neurophysiology
dc.rightsopenAccess
dc.subjectMetallothioneins
dc.subjectzinc homeostasis
dc.subjectgliosis
dc.subjectepilepsy
dc.subjectneuronal density
dc.subjectMetalotioneínas
dc.subjecthomeostase do zinco
dc.subjectgliose
dc.subjectepilepsia
dc.subjectdensidade neuronal
dc.titleDifferent levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?
dc.titleNíveis diferentes de MT-I/II entre pacientes com MTLE com ou sem crise generalizada: os níveis hipocampais de MT-I/II afetam o alastramento das crises, ou o alastramento das crises promove expressão diferencial de MT-I/II?
dc.typeArtículos de revistas


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