Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?
Níveis diferentes de MT-I/II entre pacientes com MTLE com ou sem crise generalizada: os níveis hipocampais de MT-I/II afetam o alastramento das crises, ou o alastramento das crises promove expressão diferencial de MT-I/II?
dc.creator | Peixoto-Santos, José Eduardo | |
dc.creator | Galvis-Alonso, Orfa Yineth | |
dc.creator | Velasco, Tonicarlo R. | |
dc.creator | Kandratavicius, Ludmyla | |
dc.creator | Assirati Jr, João Alberto | |
dc.creator | Carlotti, Carlos Gilberto | |
dc.creator | Scandiuzzi, Renata Caldo | |
dc.creator | Serafini, Luciano Neder | |
dc.creator | Leite, João Pereira | |
dc.date.accessioned | 2013-11-04T12:53:14Z | |
dc.date.accessioned | 2018-07-04T16:38:28Z | |
dc.date.available | 2013-11-04T12:53:14Z | |
dc.date.available | 2018-07-04T16:38:28Z | |
dc.date.created | 2013-11-04T12:53:14Z | |
dc.date.issued | 2012 | |
dc.identifier | J. epilepsy clin. neurophysiol.,v.18,n.1,p.16-20,2012 | |
dc.identifier | 1676-2649 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/40112 | |
dc.identifier | 10.1590/S1676-26492012000100005 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1638345 | |
dc.description.abstract | In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns. | |
dc.language | eng | |
dc.publisher | Liga Brasileira de Epilepsia (LBE) | |
dc.relation | Journal of Epilepsy and Clinical Neurophysiology | |
dc.rights | openAccess | |
dc.subject | Metallothioneins | |
dc.subject | zinc homeostasis | |
dc.subject | gliosis | |
dc.subject | epilepsy | |
dc.subject | neuronal density | |
dc.subject | Metalotioneínas | |
dc.subject | homeostase do zinco | |
dc.subject | gliose | |
dc.subject | epilepsia | |
dc.subject | densidade neuronal | |
dc.title | Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II? | |
dc.title | Níveis diferentes de MT-I/II entre pacientes com MTLE com ou sem crise generalizada: os níveis hipocampais de MT-I/II afetam o alastramento das crises, ou o alastramento das crises promove expressão diferencial de MT-I/II? | |
dc.type | Artículos de revistas |