Artículos de revistas
Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia
Rev. Bras. Hematol. Hemoter.,v.34,n.2,p.134-139,2012
Bassi, Sarah Cristina
Rego, Eduardo Magalhães
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid receptor alpha rearrangement. This rearrangement interacts with several proteins, including the native promyelocytic leukemia gene, thus causing its delocalization from the nuclear bodies, impairing its function. The immunofluorescence staining technique using the anti-PML antibody may be used to provide a rapid diagnosis and to immediately start therapy using all-trans retinoic acid. The experience of the International Consortium on Acute Promyelocytic Leukemia has demonstrated that early mortality was significantly reduced by adopting the immunofluorescence technique. All-trans retinoic acid combined with chemotherapy is the standard therapy; this promotes complete remission rates greater than 90% and cure rates of nearly 80%. However, early mortality is still an important limitation and hematologists must be aware of the importance of treating newly diagnosed acute promyelocytic leukemia as a medical emergency.
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Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines. Sanghamitra Khandual; FLOR YOHANA FLORES HERNANDEZ; INOCENCIA GUADALUPE RAMIREZ LOPEZ
A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? Campos, Mireille Guimarães Vaz de; Chauffaille, Maria de Lourdes Lopes Ferrari; Rodrigues, Celso Arrais; Krum, Everson A.; Yamamoto, Mihoko (Sociedade Brasileira de Genética, 2003-01-01)The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in ...
Current Patient Management of Chronic Myeloid Leukemia in Latin America A Study by the Latin American Leukemia Net (LALNET) CORTES, Jorge; SOUZA, Carmino De; AYALA-SANCHEZ, Manuel; BENDIT, Israel; BEST-AGUILERA, Carlos; ENRICO, Alicia; HAMERSCHLAK, Nelson; PAGNANO, Katia; PASQUINI, Ricardo; MEILLON, Luis (JOHN WILEY & SONS INC, 2010)BACKGROUND: Treatment recommendations have been developed for management of patients with chronic myeloid leukemia (CML). METHODS: A 30-item multiple-choice questionnaire was administered to 435 hematologists and ...