Artículos de revistas
Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
Revisão de modelos experimentais de cirrose hepática induzida por ligadura do ducto biliar e por injeção de tetracloreto de carbono
Fecha
2012Registro en:
Acta Cir. Bras.,v.27,n.8,p.589-594,2012
0102-8650
10.1590/S0102-86502012000800013
Autor
Marques, Thamirys Guimarães
Chaib, Eleazar
Fonseca, Juliana Hamati da
Lourenço, Ana Cecília Rodrigues
Silva, Felipe Duarte
Ribeiro Jr, Marcelo Augusto Fontenelle
Galvão, Flavio Henrique Ferreira
D'Albuquerque, Luiz Augusto Carneiro
Institución
Resumen
PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.