Efeito da evolução temporal da adrenalectomia na secreção de prolactina

dc.creatorLaguna-Abreu, Maria Thereza C.
dc.creatorGermano, Carla
dc.creatorMoreira, Ayrton C.
dc.creatorAntunes-Rodrigues, José
dc.creatorElias, Lucila
dc.creatorCastro, Margaret
dc.date.accessioned2013-11-04T11:51:50Z
dc.date.accessioned2018-07-04T16:31:11Z
dc.date.available2013-11-04T11:51:50Z
dc.date.available2018-07-04T16:31:11Z
dc.date.created2013-11-04T11:51:50Z
dc.date.issued2012
dc.identifierArq Bras Endocrinol Metab,v.56,n.4,p.244-249,2012
dc.identifier0004-2730
dc.identifierhttp://www.producao.usp.br/handle/BDPI/38041
dc.identifier10.1590/S0004-27302012000400005
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1636707
dc.description.abstractOBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX.
dc.languageeng
dc.publisherSociedade Brasileira de Endocrinologia e Metabologia
dc.relationArquivos Brasileiros de Endocrinologia & Metabologia
dc.rightsopenAccess
dc.subjectAdrenalectomy
dc.subjectprolactin
dc.subjectcorticosterone
dc.subjectadrenocorticotropic hormone
dc.subjectAdrenalectomia
dc.subjectprolactina
dc.subjectcorticosterona
dc.subjecthormônio adrenocorticotrófico
dc.titleChanges in prolactin secretion in the short- and long-term after adrenalectomy
dc.titleEfeito da evolução temporal da adrenalectomia na secreção de prolactina
dc.typeArtículos de revistas


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