Changes in prolactin secretion in the short- and long-term after adrenalectomy
Efeito da evolução temporal da adrenalectomia na secreção de prolactina
dc.creator | Laguna-Abreu, Maria Thereza C. | |
dc.creator | Germano, Carla | |
dc.creator | Moreira, Ayrton C. | |
dc.creator | Antunes-Rodrigues, José | |
dc.creator | Elias, Lucila | |
dc.creator | Castro, Margaret | |
dc.date.accessioned | 2013-11-04T11:51:50Z | |
dc.date.accessioned | 2018-07-04T16:31:11Z | |
dc.date.available | 2013-11-04T11:51:50Z | |
dc.date.available | 2018-07-04T16:31:11Z | |
dc.date.created | 2013-11-04T11:51:50Z | |
dc.date.issued | 2012 | |
dc.identifier | Arq Bras Endocrinol Metab,v.56,n.4,p.244-249,2012 | |
dc.identifier | 0004-2730 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/38041 | |
dc.identifier | 10.1590/S0004-27302012000400005 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1636707 | |
dc.description.abstract | OBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX. | |
dc.language | eng | |
dc.publisher | Sociedade Brasileira de Endocrinologia e Metabologia | |
dc.relation | Arquivos Brasileiros de Endocrinologia & Metabologia | |
dc.rights | openAccess | |
dc.subject | Adrenalectomy | |
dc.subject | prolactin | |
dc.subject | corticosterone | |
dc.subject | adrenocorticotropic hormone | |
dc.subject | Adrenalectomia | |
dc.subject | prolactina | |
dc.subject | corticosterona | |
dc.subject | hormônio adrenocorticotrófico | |
dc.title | Changes in prolactin secretion in the short- and long-term after adrenalectomy | |
dc.title | Efeito da evolução temporal da adrenalectomia na secreção de prolactina | |
dc.type | Artículos de revistas |