Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study

dc.creatorSantos, Petra dos
dc.creatorZanetti, Juliana da Silva
dc.creatorSilva, Alfredo Ribeiro da
dc.creatorBeltrão, Eduardo IC
dc.date.accessioned2013-10-14T17:52:10Z
dc.date.accessioned2018-07-04T16:30:22Z
dc.date.available2013-10-14T17:52:10Z
dc.date.available2018-07-04T16:30:22Z
dc.date.created2013-10-14T17:52:10Z
dc.date.issued2012-08-16
dc.identifierDIAGNOSTIC PATHOLOGY, LONDON, v. 7, AUG 16, 2012
dc.identifier1746-1596
dc.identifierhttp://www.producao.usp.br/handle/BDPI/34857
dc.identifierhttp://dx.doi.org/10.1186/1746-1596-7-104
dc.identifier10.1186/1746-1596-7-104
dc.identifierhttp://www.diagnosticpathology.org/content/7/1/104
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1636517
dc.description.abstractAbstract Background The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment. Integrins, a family of transmembrane glycoproteins, play a major role in invasive and metastatic processes. Integrins are involved in cell adhesion in both cell-extracellular matrix and cell-cell interactions, and particularly, β1 integrin is involved in proliferation and differentiation of cells in the development of epithelial tissues. This work aimed to investigate the putative role of β1 integrin expression on survival and metastasis in patients with breast invasive ductal carcinoma (IDC). In addition, we compared the expression of β1 integrin in patients with ductal carcinoma in situ (DCIS). Methods Through tissue microarray (TMA) slides containing 225 samples of IDC and 67 samples of DCIS, β1 integrin expression was related with several immunohistochemical markers and clinicopathologic features of prognostic significance. Results β1 integrin was overexpressed in 32.8% of IDC. In IDC, β1 integrin was related with HER-2 (p = 0.019) and VEGF (p = 0.011) expression and it had a significant relationship with metastasis and death (p = 0.001 and p = 0.05, respectively). Kaplan-Meier survival analysis showed that the overexpression of this protein is very significant (p = 0.002) in specific survival (number of months between diagnosis and death caused by the disease). There were no correlation between IDC and DCIS (p = 0.559) regarding β1 integrin expression. Conclusions Considering that the expression of β1 integrin in breast cancer remains controversial, specially its relation with survival of patients, our findings provide further evidence that β1 integrin can be a marker of poor prognosis in breast cancer. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6652215267393871
dc.languageeng
dc.publisherLONDON
dc.relationDiagnostic Pathology
dc.rightsdos Santos et al.; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rightsopenAccess
dc.subjectBETA 1 INTEGRIN; TISSUE MICROARRAY; IMMUNOHISTOCHEMISTRY; PROGNOSIS;
dc.titleBeta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución