A Facile, Versatile, and Mild Morita-Baylis-Hillman-Type Reaction for the Modular One-Pot Synthesis of Highly Functionalized MBH Adducts

dc.creatorSousa, Bruno A.
dc.creatorSantos, Alcindo Aparecido dos
dc.date.accessioned2013-09-11T12:39:07Z
dc.date.accessioned2018-07-04T16:26:27Z
dc.date.available2013-09-11T12:39:07Z
dc.date.available2018-07-04T16:26:27Z
dc.date.created2013-09-11T12:39:07Z
dc.date.issued2012
dc.identifierEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WEINHEIM, v. 752, n. 18, pp. 3431-3436, JUN, 2012
dc.identifier1434-193X
dc.identifierhttp://www.producao.usp.br/handle/BDPI/33253
dc.identifier10.1002/ejoc.201200371
dc.identifierhttp://dx.doi.org/10.1002/ejoc.201200371
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1635875
dc.description.abstractMoritaBaylisHillman derivatives have been extensively investigated as intermediates in the preparation of important classes of compounds. However, there are intrinsic limitations regarding the structure of the Michael electrophile acceptors, the aldehydes, and the catalysts. Therefore, this transformation has several drawbacks, including, for example, its long reaction times. Herein we present a simple, general, fast, and high-yielding protocol for the one-pot synthesis of MoritaBaylisHillman derivatives. Our approach is driven by a lithium selenolate Michael/aldol operation with concomitant O-functionalization/selenoxide elimination cascade sequences.
dc.languageeng
dc.publisherWiley-V C H Verlag GmbH
dc.publisherWEINHEIM
dc.relationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
dc.rightsCopyright WILEY-V C H VERLAG GMBH
dc.rightsclosedAccess
dc.subjectMULTICOMPONENT REACTIONS
dc.subjectDOMINO REACTIONS
dc.subjectMICHAEL ADDITION
dc.subjectALDOL REACTIONS
dc.subjectSELENIUM
dc.titleA Facile, Versatile, and Mild Morita-Baylis-Hillman-Type Reaction for the Modular One-Pot Synthesis of Highly Functionalized MBH Adducts
dc.typeArtículos de revistas


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