dc.creatorRead, Jennifer S.
dc.creatorCohen, Rachel A.
dc.creatorHance, Laura Freimanis
dc.creatorMachado, Elizabeth S.
dc.creatorMussi-Pinhata, Marisa M.
dc.creatorCeriotto, Mariana
dc.creatorSantos, Breno
dc.creatorSucci, Regina
dc.creatorPilotto, Jose H.
dc.creatorAlarcon, Jorge O.
dc.creatorKreitchmann, Regis
dc.date.accessioned2013-09-11T12:31:11Z
dc.date.accessioned2018-07-04T16:26:27Z
dc.date.available2013-09-11T12:31:11Z
dc.date.available2018-07-04T16:26:27Z
dc.date.created2013-09-11T12:31:11Z
dc.date.issued2012
dc.identifierINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Clare, v. 119, n. 1, pp. 70-75, OCT, 2012
dc.identifier0020-7292
dc.identifierhttp://www.producao.usp.br/handle/BDPI/33252
dc.identifier10.1016/j.ijgo.2012.05.026
dc.identifierhttp://dx.doi.org/10.1016/j.ijgo.2012.05.026
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1635874
dc.description.abstractObjective: To evaluate cases of mother-to-child transmission of HIV-1 at multiple sites in Latin America and the Caribbean in terms of missed opportunities for prevention. Methods: Pregnant women infected with HIV-1 were eligible for inclusion if they were enrolled in either the NISDI Perinatal or LILAC protocols by October 20, 2009, and had delivered a live infant with known HIV-1 infection status after March 1, 2006. Results: Of 711 eligible mothers, 10 delivered infants infected with HIV-1. The transmission rate was 1.4% (95% CI, 0.7-2.6). Timing of transmission was in utero or intrapartum (n = 5), intrapartum (n = 2), intrapartum or early postnatal (n = 1), and unknown (n = 2). Possible missed opportunities for prevention included poor control of maternal viral load during pregnancy; late initiation of antiretrovirals during pregnancy; lack of cesarean delivery before labor and before rupture of membranes; late diagnosis of HIV-1 infection; lack of intrapartum antiretrovirals; and incomplete avoidance of breastfeeding. Conclusion: Early knowledge of HIV-1 infection status (ideally before or in early pregnancy) would aid timely initiation of antiretroviral treatment and strategies designed to prevent mother-to-child transmission. Use of antiretrovirals must be appropriately monitored in terms of adherence and drug resistance. If feasible, breastfeeding should be completely avoided. Presented in part at the XIX International AIDS Conference (Washington, DC; July 22-27, 2012); abstract WEPE163. (c) 2012 Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics.
dc.languageeng
dc.publisherELSEVIER IRELAND LTD
dc.publisherClare
dc.relationINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
dc.rightsCopyright ELSEVIER IRELAND LTD
dc.rightsclosedAccess
dc.subjectHIV-1
dc.subjectMOTHER-TO-CHILD TRANSMISSION
dc.subjectPREVENTION
dc.titleMissed opportunities for prevention of mother-to-child transmission of HIV-1 in the NISDI Perinatal and LILAC cohorts
dc.typeArtículos de revistas


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