dc.creatorSampaio Góes, Renata
dc.creatorCarvalho, Jesus P.
dc.creatorAlmeida, Bernardo G. L.
dc.creatorBacchi, Carlos E.
dc.creatorSampaio Goes, Joao Carlos
dc.creatorCalil, Marcelo Alvarenga
dc.creatorBaracat, Edmund C.
dc.creatorCarvalho, Filomena M.
dc.date.accessioned2013-11-07T11:17:45Z
dc.date.accessioned2018-07-04T16:24:51Z
dc.date.available2013-11-07T11:17:45Z
dc.date.available2018-07-04T16:24:51Z
dc.date.created2013-11-07T11:17:45Z
dc.date.issued2012
dc.identifierINTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, PHILADELPHIA, v. 31, n. 1, pp. 8-14, JAN, 2012
dc.identifier0277-1691
dc.identifierhttp://www.producao.usp.br/handle/BDPI/42964
dc.identifier10.1097/PGP.0b013e31821f4de2
dc.identifierhttp://dx.doi.org/10.1097/PGP.0b013e31821f4de2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1635520
dc.description.abstractLymphatic vessels serve as major routes for regional dissemination, and therefore, lymph node status is a key indicator of prognosis. To predict lymph node metastasis, tumor lymphatic density and lymphangiogenesis-related molecules have been studied in various tumor types. To our knowledge, no previous studies have evaluated the role of intratumoral lymphatic vessel density (LVD) in the behavior of vulvar carcinomas. The aim of this study was to analyze intratumoral LVD in relation to patient survival and well-characterized prognostic factors for cancer. Thirty-five patients with vulvar squamous cell carcinoma underwent vulvectomy and dissection of regional lymph nodes. Clinical records were reviewed, in addition to histological grade, peritumoral lymphatic invasion, and depth of infiltration for each case. Tissue microarray paraffin blocks were created, and lymphatic vessels were detected using immunohistochemical staining of podoplanin (D2-40 antibody). Intratumoral LVD was quantified by counting the number of stained vessels. Higher values for intratumoral LVD were associated with low-grade and low-stage tumors, and with tumors without lymphatic invasion and reduced stromal infiltration. In a univariate analysis, high intratumoral LVD was associated with a higher rate of overall survival and a lower rate of lymph node metastasis. Our results suggest that increased intratumoral LVD is associated with favorable prognosis in vulvar squamous carcinomas.
dc.languageeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.publisherPHILADELPHIA
dc.relationINTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
dc.rightsCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.rightsclosedAccess
dc.subjectVULVAR CANCER
dc.subjectLYMPHANGIOGENESIS
dc.subjectPROGNOSTIC FACTORS
dc.subjectPODOPLANIN
dc.subjectLYMPHATIC VESSELS
dc.titleIntratumoral Lymphatic Vessel Density in Vulvar Squamous Cell Carcinomas: A Possible Association With Favorable Prognosis
dc.typeArtículos de revistas


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