Artículos de revistas
Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy
Date
2012Registration in:
MOVEMENT DISORDERS, HOBOKEN, v. 27, n. 12, pp. 1559-1563, OCT, 2012
0885-3185
10.1002/mds.25127
Author
Fonoff, Erich Talamoni
Campos, Wuilker Knoner
Mandel, Mauricio
Lopes Alho, Eduardo Joaquim
Teixeira, Manoel Jacobsen
Institutions
Abstract
Background: Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities. Methods: Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the BurkeFahnMarsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery. Results: All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025). Conclusions: These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy. (c) 2012 Movement Disorder Society