dc.creator | de Medeiros, Alexandra Ivo | |
dc.creator | Gandolfi, Renata Cristina | |
dc.creator | Secatto, Adriana | |
dc.creator | Falcucci, Romulo Martelli | |
dc.creator | Faccioli, Lucia Helena | |
dc.creator | Hajdu, Eduardo | |
dc.creator | Peixinho, Solange | |
dc.creator | Berlinck, Roberto Gomes de Souza | |
dc.date.accessioned | 2013-11-06T19:22:13Z | |
dc.date.accessioned | 2018-07-04T16:20:01Z | |
dc.date.available | 2013-11-06T19:22:13Z | |
dc.date.available | 2018-07-04T16:20:01Z | |
dc.date.created | 2013-11-06T19:22:13Z | |
dc.date.issued | 2012 | |
dc.identifier | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, LONDON, v. 34, n. 6, supl. 4, Part 1-2, pp. 919-924, DEC, 2012 | |
dc.identifier | 0892-3973 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/42683 | |
dc.identifier | 10.3109/08923973.2012.679984 | |
dc.identifier | http://dx.doi.org/10.3109/08923973.2012.679984 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1634500 | |
dc.description.abstract | Marine sponges of the order Verongida are a rich source of biologically active bromotyrosine-derived secondary metabolites. However, none of these compounds are known to display anti-inflammatory activity. In the present investigation, we report the anti-inflammatory effects of 11-oxoaerothionin isolated from the Verongida sponge Aplysina fistularis. When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS (inducible nitric oxide synthase) protein and NO2- (Nitrite) production were observed. The same effect was observed when proinflammatory cytokines and PGE(2) (Prostaglandin E2) production was evaluated. In summary, we demonstrated that in the presence of LPS, 11-oxoaerothionin suppresses NO2 and iNOS expression as well as inflammatory cytokines and PGE(2). | |
dc.language | eng | |
dc.publisher | INFORMA HEALTHCARE | |
dc.publisher | LONDON | |
dc.relation | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | |
dc.rights | Copyright INFORMA HEALTHCARE | |
dc.rights | closedAccess | |
dc.subject | PROSTAGLANDIN E2 | |
dc.subject | MACROPHAGES | |
dc.subject | INFLAMMATORY CYTOKINES | |
dc.subject | NITRIC OXIDE | |
dc.subject | NF-KAPPA B AND LIPOPOLYSACCHARIDE | |
dc.title | 11-Oxoaerothionin isolated from the marine sponge Aplysina fistularis shows anti-inflammatory activity in LPS-stimulated macrophages | |
dc.type | Artículos de revistas | |