Artículos de revistas
Dose and latency effects of leucine supplementation in modulating glucose homeostasis: opposite effects in healthy and glucocorticoid-induced insulin-resistance states
Fecha
2012Registro en:
NUTRIENTS, BASEL, v. 4, n. 12, supl. 1, Part 2, pp. 1851-1867, DEC, 2012
2072-6643
10.3390/nu4121851
Autor
Zanchi, Nelo Eidy
Guimaraes-Ferreira, Lucas
Siqueira-Filho, Mario Alves de
Felitti, Vitor
Nicastro, Humberto
Bueno Júnior, Carlos Roberto
Lira, Fabio Santos
Naimo, Marshall Alan
Campos-Ferraz, Patricia
Nunes, Maria Tereza
Seelaender, Marilia
Carvalho, Carla Roberta de Oliveira
Blachier, Francois
Lancha Junior, Antonio Herbert
Institución
Resumen
Dexamethasone (DEXA) is a potent immunosupressant and anti-inflammatory agent whose main side effects are muscle atrophy and insulin resistance in skeletal muscles. In this context, leucine supplementation may represent a way to limit the DEXA side effects. In this study, we have investigated the effects of a low and a high dose of leucine supplementation (via a bolus) on glucose homeostasis, muscle mass and muscle strength in energy-restricted and DEXA-treated rats. Since the leucine response may also be linked to the administration of this amino acid, we performed a second set of experiments with leucine given in bolus (via gavage) versus leucine given via drinking water. Leucine supplementation was found to produce positive effects (e. g., reduced insulin levels) only when administrated in low dosage, both via the bolus or via drinking water. However, under DEXA treatment, leucine administration was found to significantly influence this response, since leucine supplementation via drinking water clearly induced a diabetic state, whereas the same effect was not observed when supplied via the gavage.