dc.creator | Siberry, George K. | |
dc.creator | Harris, D. Robert | |
dc.creator | Oliveira, Ricardo Hugo | |
dc.creator | Krauss, Margot R. | |
dc.creator | Hofer, Cristina B. | |
dc.creator | Barbaro, Adriana Aparecida Tiraboschi | |
dc.creator | Marques, Heloisa | |
dc.creator | Succi, Regina C. | |
dc.creator | Abreu, Thalita | |
dc.creator | Della Negra, Marinella | |
dc.creator | Mofenson, Lynne M. | |
dc.creator | Hazra, Rohan | |
dc.date.accessioned | 2013-11-06T19:05:50Z | |
dc.date.accessioned | 2018-07-04T16:19:36Z | |
dc.date.available | 2013-11-06T19:05:50Z | |
dc.date.available | 2018-07-04T16:19:36Z | |
dc.date.created | 2013-11-06T19:05:50Z | |
dc.date.issued | 2012 | |
dc.identifier | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, PHILADELPHIA, v. 60, n. 2, pp. 214-218, JUN 01, 2012 | |
dc.identifier | 1525-4135 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/42609 | |
dc.identifier | 10.1097/QAI.0b013e31824e4da6 | |
dc.identifier | http://journals.lww.com/jaids/toc/2012/06010 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1634416 | |
dc.description.abstract | Background: This study evaluated a wide range of viral load (VL) thresholds to identify a cut-point that best predicts new clinical events in children on stable highly active antiretroviral therapy (HAART). Methods: Cox proportional hazards modeling was used to assess the adjusted risk for World Health Organization stage 3 or 4 clinical events (WHO events) as a function of time-varying CD4, VL, and hemoglobin values in a cohort study of Latin American children on HAART >= 6 months. Models were fit using different VL cut-points between 400 and 50,000 copies per milliliter, with model fit evaluated on the basis of the minimum Akaike information criterion value, a standard model fit statistic. Results: Models were based on 67 subjects with WHO events out of 550 subjects on study. The VL cut-points of >2600 and >32,000 copies per milliliter corresponded to the lowest Akaike information criterion values and were associated with the highest hazard ratios (2.0, P = 0.015; and 2.1, P = 0.0058, respectively) for WHO events. Conclusions: In HIV-infected Latin American children on stable HAART, 2 distinct VL thresholds (>2600 and >32,000 copies/mL) were identified for predicting children at significantly increased risk for HIV-related clinical illness, after accounting for CD4 level, hemoglobin level, and other significant factors. | |
dc.language | eng | |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | |
dc.publisher | PHILADELPHIA | |
dc.relation | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | |
dc.rights | Copyright LIPPINCOTT WILLIAMS & WILKINS | |
dc.rights | openAccess | |
dc.subject | PEDIATRIC HIV INFECTION | |
dc.subject | VIRAL LOAD MONITORING | |
dc.subject | VIRAL LOAD THRESHOLD | |
dc.subject | LATIN AMERICA | |
dc.title | Evaluation of Viral Load Thresholds for Predicting New World Health Organization Stage 3 and 4 Events in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy | |
dc.type | Artículos de revistas | |