dc.creatorArashiro, Roberta Thiery de Godoy
dc.creatorTeixeira, Magaly Gemio
dc.creatorRawet, Viviane
dc.creatorQuintanilha, Alina Guimaraes
dc.creatorPaula, Henrique Moura de
dc.creatorSilva, Adriano Zanon
dc.creatorNahas, Sergio Carlos
dc.creatorCecconello, Ivan
dc.date.accessioned2013-11-06T15:15:12Z
dc.date.accessioned2018-07-04T16:19:07Z
dc.date.available2013-11-06T15:15:12Z
dc.date.available2018-07-04T16:19:07Z
dc.date.created2013-11-06T15:15:12Z
dc.date.issued2012
dc.identifierCLINICS, SAO PAULO, v. 67, n. 7, pp. 705-710, JUL, 2012
dc.identifier1807-5932
dc.identifierhttp://www.producao.usp.br/handle/BDPI/42143
dc.identifier10.6061/clinics/2012(07)02
dc.identifierhttp://dx.doi.org/10.6061/clinics/2012(07)02
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1634312
dc.description.abstractOBJECTIVE: Many changes in mucosal morphology are observed following ileal pouch construction, including colonic metaplasia and dysplasia. Additionally, one rare but potential complication is the development of adenocarcinoma of the reservoir. The aim of this study was to evaluate the most frequently observed histopathological changes in ileal pouches and to correlate these changes with potential risk factors for complications. METHODS: A total of 41 patients were enrolled in the study and divided into the following three groups: a non-pouchitis group (group 1) (n = 20; 8 males; mean age: 47.5 years) demonstrating optimal outcome; a pouchitis without antibiotics group (group 2) (n = 14; 4 males; mean age: 47 years), containing individuals with pouchitis who did not receive treatment with antibiotics; and a pouchitis plus antibiotics group (group 3) (n = 7; 3 males; mean age: 41 years), containing those patients with pouchitis who were administered antibiotics. Ileal pouch endoscopy was performed, and tissue biopsy samples were collected for histopathological analysis. RESULTS: Colonic metaplasia was found in 15 (36.6%) of the 41 patients evaluated; of these, five (25%) were from group 1, eight (57.1%) were from group 2, and two (28.6%) were from group 3. However, no correlation was established between the presence of metaplasia and pouchitis (p = 0.17). and no differences in mucosal atrophy or the degree of chronic or acute inflammation were observed between groups 1, 2, and 3 (p > 0.45). Moreover, no dysplasia or neoplastic changes were detected. However, the degree of mucosal atrophy correlated well with the time of postoperative follow-up (p = 0.05). CONCLUSIONS: The degree of mucosal atrophy, the presence of colonic metaplasia, and the degree of acute or chronic inflammation do not appear to constitute risk factors for the development of pouchitis. Moreover, we observed that longer postoperative follow-up times were associated with greater degrees of mucosal atrophy.
dc.languageeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.publisherSAO PAULO
dc.relationCLINICS
dc.rightsCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.rightsopenAccess
dc.subjectCOLONIC METAPLASIA
dc.subjectATROPHY
dc.subjectILEAL POUCH
dc.subjectPOUCHITIS
dc.subjectPROCTOCOLECTOMY
dc.titleHistopathological evaluation and risk factors related to the development of pouchitis in patients with ileal pouches for ulcerative colitis
dc.typeArtículos de revistas


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