dc.creator | de Carvalho, Jozelio Freire | |
dc.creator | Pasoto, Sandra Gofinet | |
dc.creator | Appenzeller, Simone | |
dc.date.accessioned | 2013-10-25T18:04:43Z | |
dc.date.accessioned | 2018-07-04T16:18:28Z | |
dc.date.available | 2013-10-25T18:04:43Z | |
dc.date.available | 2018-07-04T16:18:28Z | |
dc.date.created | 2013-10-25T18:04:43Z | |
dc.date.issued | 2012 | |
dc.identifier | CLINICAL & DEVELOPMENTAL IMMUNOLOGY, NEW YORK, v. 126, n. 6, supl., Part 3, pp. 826-834, DEC, 2012 | |
dc.identifier | 1740-2522 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/36104 | |
dc.identifier | 10.1155/2012/981519 | |
dc.identifier | http://dx.doi.org/10.1155/2012/981519 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1634171 | |
dc.description.abstract | Objectives. To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. Methods. Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. Results. Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. Conclusion. About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke. | |
dc.language | eng | |
dc.publisher | HINDAWI PUBLISHING CORPORATION | |
dc.publisher | NEW YORK | |
dc.relation | CLINICAL & DEVELOPMENTAL IMMUNOLOGY | |
dc.rights | Copyright HINDAWI PUBLISHING CORPORATION | |
dc.rights | openAccess | |
dc.title | Seizures in Primary Antiphospholipid Syndrome: The Relevance of Smoking to Stroke | |
dc.type | Artículos de revistas | |