dc.creator | Souza, Claudia R. F. | |
dc.creator | Oliveira, Wanderley P. | |
dc.date.accessioned | 2013-11-05T14:59:49Z | |
dc.date.accessioned | 2018-07-04T16:18:27Z | |
dc.date.available | 2013-11-05T14:59:49Z | |
dc.date.available | 2018-07-04T16:18:27Z | |
dc.date.created | 2013-11-05T14:59:49Z | |
dc.date.issued | 2012 | |
dc.identifier | DRYING TECHNOLOGY, PHILADELPHIA, v. 30, n. 3, supl. 4, Part 1, pp. 263-275, JAN-FEB, 2012 | |
dc.identifier | 0737-3937 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/41593 | |
dc.identifier | 10.1080/07373937.2011.635252 | |
dc.identifier | http://dx.doi.org/10.1080/07373937.2011.635252 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1634164 | |
dc.description.abstract | Microparticles of ketoprofen entrapped in blends of acrylic resins (Eudragit RL 30D and RS 30D) were successfully produced by spray drying. The effects of the proportion ketoprofen : polymer (1: 1 and 1: 3) and of spray-drying parameters (drying gas inlet temperatures of 80 and 100 degrees C; microencapsulating composition feed flow rates of 4 and 6 g/min) on the microparticles properties (drug content, encapsulation efficiency, mean particle size, moisture content, and dissolution behavior) were evaluated. Differential scanning calorimetry (DSC) thermograms and X-ray diffractograms of the spray-dried product, the free drug, and the physical mixture between the free drug and spray-dried composition (blank) were carried out. Microparticles obtained at inlet temperature of 80 degrees C, feed flow rate of 4 g/min, and ketoprofen : acrylic resin ratio of 1: 3 presented an encapsulation efficiency of 88.1%, moisture content of 5.8%, production yield around 50%, and a higher reduction in dissolution rate of the entrapped ketoprofen. Sigmoidal shape dissolution profiles were presented by the spray-dried microparticles. The dissolution profiles were relatively well described by the Weibull model, a showing high coefficient of determination, R-2, and a mean absolute error between experimental and estimated values of between 4.6 and 10.1%. | |
dc.language | eng | |
dc.publisher | TAYLOR & FRANCIS INC | |
dc.publisher | PHILADELPHIA | |
dc.relation | DRYING TECHNOLOGY | |
dc.rights | Copyright TAYLOR & FRANCIS INC | |
dc.rights | restrictedAccess | |
dc.subject | ACRYLIC RESINS | |
dc.subject | DRUG RELEASE | |
dc.subject | MICROPARTICLES | |
dc.subject | SPRAY DRYING | |
dc.subject | WEIBULL MODEL | |
dc.title | Microencapsulation of Ketoprofen in Blends of Acrylic Resins by Spray Drying | |
dc.type | Artículos de revistas | |