dc.creatorSouza, Claudia R. F.
dc.creatorOliveira, Wanderley P.
dc.date.accessioned2013-11-05T14:59:49Z
dc.date.accessioned2018-07-04T16:18:27Z
dc.date.available2013-11-05T14:59:49Z
dc.date.available2018-07-04T16:18:27Z
dc.date.created2013-11-05T14:59:49Z
dc.date.issued2012
dc.identifierDRYING TECHNOLOGY, PHILADELPHIA, v. 30, n. 3, supl. 4, Part 1, pp. 263-275, JAN-FEB, 2012
dc.identifier0737-3937
dc.identifierhttp://www.producao.usp.br/handle/BDPI/41593
dc.identifier10.1080/07373937.2011.635252
dc.identifierhttp://dx.doi.org/10.1080/07373937.2011.635252
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1634164
dc.description.abstractMicroparticles of ketoprofen entrapped in blends of acrylic resins (Eudragit RL 30D and RS 30D) were successfully produced by spray drying. The effects of the proportion ketoprofen : polymer (1: 1 and 1: 3) and of spray-drying parameters (drying gas inlet temperatures of 80 and 100 degrees C; microencapsulating composition feed flow rates of 4 and 6 g/min) on the microparticles properties (drug content, encapsulation efficiency, mean particle size, moisture content, and dissolution behavior) were evaluated. Differential scanning calorimetry (DSC) thermograms and X-ray diffractograms of the spray-dried product, the free drug, and the physical mixture between the free drug and spray-dried composition (blank) were carried out. Microparticles obtained at inlet temperature of 80 degrees C, feed flow rate of 4 g/min, and ketoprofen : acrylic resin ratio of 1: 3 presented an encapsulation efficiency of 88.1%, moisture content of 5.8%, production yield around 50%, and a higher reduction in dissolution rate of the entrapped ketoprofen. Sigmoidal shape dissolution profiles were presented by the spray-dried microparticles. The dissolution profiles were relatively well described by the Weibull model, a showing high coefficient of determination, R-2, and a mean absolute error between experimental and estimated values of between 4.6 and 10.1%.
dc.languageeng
dc.publisherTAYLOR & FRANCIS INC
dc.publisherPHILADELPHIA
dc.relationDRYING TECHNOLOGY
dc.rightsCopyright TAYLOR & FRANCIS INC
dc.rightsrestrictedAccess
dc.subjectACRYLIC RESINS
dc.subjectDRUG RELEASE
dc.subjectMICROPARTICLES
dc.subjectSPRAY DRYING
dc.subjectWEIBULL MODEL
dc.titleMicroencapsulation of Ketoprofen in Blends of Acrylic Resins by Spray Drying
dc.typeArtículos de revistas


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