Brazilian urban population genetic structure reveals a high degree of admixture

dc.creatorGiolo, Suely R.
dc.creatorSoler, Julia M. P.
dc.creatorGreenway, Steven C.
dc.creatorAlmeida, Marcio A. A.
dc.creatorAndrade, Mariza de
dc.creatorSeidman, J. G.
dc.creatorSeidman, Christine E.
dc.creatorKrieger, Jose E.
dc.creatorPereira, Alexandre C.
dc.date.accessioned2013-11-06T16:19:24Z
dc.date.accessioned2018-07-04T16:16:26Z
dc.date.available2013-11-06T16:19:24Z
dc.date.available2018-07-04T16:16:26Z
dc.date.created2013-11-06T16:19:24Z
dc.date.issued2012
dc.identifierEUROPEAN JOURNAL OF HUMAN GENETICS, LONDON, v. 20, pp. 111-116, JAN, 2012
dc.identifier1018-4813
dc.identifierhttp://www.producao.usp.br/handle/BDPI/42318
dc.identifier10.1038/ejhg.2011.144
dc.identifierhttp://dx.doi.org/10.1038/ejhg.2011.144
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1633710
dc.description.abstractAdvances in genotyping technologies have contributed to a better understanding of human population genetic structure and improved the analysis of association studies. To analyze patterns of human genetic variation in Brazil, we used SNP data from 1129 individuals - 138 from the urban population of Sao Paulo, Brazil, and 991 from 11 populations of the HapMap Project. Principal components analysis was performed on the SNPs common to these populations, to identify the composition and the number of SNPs needed to capture the genetic variation of them. Both admixture and local ancestry inference were performed in individuals of the Brazilian sample. Individuals from the Brazilian sample fell between Europeans, Mexicans, and Africans. Brazilians are suggested to have the highest internal genetic variation of sampled populations. Our results indicate, as expected, that the Brazilian sample analyzed descend from Amerindians, African, and/or European ancestors, but intermarriage between individuals of different ethnic origin had an important role in generating the broad genetic variation observed in the present-day population. The data support the notion that the Brazilian population, due to its high degree of admixture, can provide a valuable resource for strategies aiming at using admixture as a tool for mapping complex traits in humans. European Journal of Human Genetics (2012) 20, 111-116; doi:10.1038/ejhg.2011.144; published online 24 August 2011
dc.languageeng
dc.publisherNATURE PUBLISHING GROUP
dc.publisherLONDON
dc.relationEUROPEAN JOURNAL OF HUMAN GENETICS
dc.rightsCopyright NATURE PUBLISHING GROUP
dc.rightsrestrictedAccess
dc.subjectGENETIC STRUCTURE
dc.subjectBRAZILIAN
dc.subjectADMIXTURE MAPPING
dc.subjectADMIXTURE
dc.titleBrazilian urban population genetic structure reveals a high degree of admixture
dc.typeArtículos de revistas


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