dc.creatorLuczyszyn, Sonia M.
dc.creatorSouza, Cleber M. de
dc.creatorBraosi, Ana P. R.
dc.creatorDirschnabel, Acir J.
dc.creatorClaudino, Marcela
dc.creatorRepeke, Carlos E.
dc.creatorFaucz, Fabio R.
dc.creatorGarlet, Gustavo P.
dc.creatorPecoits-Filho, Roberto
dc.creatorTrevilatto, Paula C.
dc.date.accessioned2013-11-06T15:40:16Z
dc.date.accessioned2018-07-04T16:14:29Z
dc.date.available2013-11-06T15:40:16Z
dc.date.available2018-07-04T16:14:29Z
dc.date.created2013-11-06T15:40:16Z
dc.date.issued2012
dc.identifierARCHIVES OF ORAL BIOLOGY, OXFORD, v. 57, n. 7, pp. 954-963, JUL, 2012
dc.identifier0003-9969
dc.identifierhttp://www.producao.usp.br/handle/BDPI/42233
dc.identifier10.1016/j.archoralbio.2012.01.013
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.01.013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1633306
dc.description.abstractChronic periodontitis (CP) and end-stage renal disease (ESRD) are complex inflammatory conditions. Higher levels of MMP-1 were found in fluids and gingival tissues from CP patients and in the blood and tissues from ESRD patients. MMP1-1607 (1G/2G) is a functional polymorphism, as it alters MMP-1 expression. Objective: The aim of this study was to investigate the association of the MMP1-1607 (1G/2G) polymorphism with CP and ESRD and evaluate differences in transcript levels between the groups. Design: A total of 254 individuals were divided into four groups: Group 1, without CP and without chronic kidney disease (CKD) (n = 67); Group 2, with CP and without CKD (n = 60); Group 3, without CP and with CKD stages (ESRD) (n = 52), and Group 4, with CP and with ESRD (n = 75). The MMP1-1607 polymorphism was analysed by PCR-RFLP. MMP1 gene transcripts from gingival tissues were analysed by real-time PCR. Results: No association was found between the MMP1-1607 polymorphism and CP or ESRD. Increased levels of MMP1 transcripts were observed in CP patients with or without ESRD. No differences were observed in the transcript levels according to the genotypes. Conclusion: It was concluded that the MMP1-1607 polymorphism was not associated with either CP or ESRD. However, higher levels of MMP1 gene transcripts were found at gingival sites of CP in patients both with and without ESRD. (C) 2012 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.publisherOXFORD
dc.relationARCHIVES OF ORAL BIOLOGY
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsclosedAccess
dc.subjectCHRONIC PERIODONTITIS
dc.subjectEND-STAGE RENAL DISEASE
dc.subjectMMP-1
dc.subjectGENETIC POLYMORPHISMS
dc.subjectTRANSCRIPT LEVELS
dc.titleAnalysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population
dc.typeArtículos de revistas


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