dc.creatorSimas, Rafael
dc.creatorKogiso, Diogo Haruo
dc.creatorCorreia, Cristiano de Jesus
dc.creatorFerraz da Silva, Luiz Fernando
dc.creatorSilva, Isaac Azevedo
dc.creatorMiranda Costa Cruz, Jose Walber
dc.creatorSannomiya, Paulina
dc.creatorPinho Moreira, Luiz Felipe
dc.date.accessioned2013-11-05T11:29:59Z
dc.date.accessioned2018-07-04T16:12:27Z
dc.date.available2013-11-05T11:29:59Z
dc.date.available2018-07-04T16:12:27Z
dc.date.created2013-11-05T11:29:59Z
dc.date.issued2012
dc.identifierACTA CIRURGICA BRASILEIRA, SAO PAULO, v. 27, n. 7, supl. 1, Part 2, pp. 465-470, JUL, 2012
dc.identifier0102-8650
dc.identifierhttp://www.producao.usp.br/handle/BDPI/41206
dc.identifier10.1590/S0102-86502012000700006 
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502012000700006 
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1632850
dc.description.abstractPURPOSE: To evaluate histopathological alterations triggered by brain death and associated trauma on different solid organs in rats. METHODS: Male Wistar rats (n=37) were anesthetized with isoflurane, intubated and mechanically ventilated. A trepanation was performed and a balloon catheter inserted into intracraninal cavity and rapidly inflated with saline to induce brain death. After induction, rats were monitored for 30, 180, and 360 min for hemodynamic parameters and exsanguinated from abdominal aorta. Heart, lung, liver, and kidney were removed and fixed in paraffin to evaluation of histological alterations (H&E). Sham-operated rats were trepanned only and used as control group. RESULTS: Brain dead rats showed a hemodynamic instability with hypertensive episode in the first minute after the induction followed by hypotension for approximately 1 h. Histological analyses showed that brain death induces vascular congestion in heart (p<0.05), and lung (p<0.05); lung alveolar edema (p=0.001), kidney tubular edema (p<0.05); and leukocyte infiltration in liver (p<0.05). CONCLUSIONS: Brain death induces hemodynamic instability associated with vascular changes in solid organs and compromises most severely the lungs. However, brain death associated trauma triggers important pathophysiological alterations in these organs.
dc.languageeng
dc.publisherACTA CIRURGICA BRASILEIRA
dc.publisherSAO PAULO
dc.relationACTA CIRURGICA BRASILEIRA
dc.rightsCopyright ACTA CIRURGICA BRASILEIRA
dc.rightsopenAccess
dc.subjectBRAIN DEATH
dc.subjectCRANIOCEREBRAL TRAUMA
dc.subjectPATHOLOGY
dc.subjectRATS
dc.titleInfluence of brain death and associated trauma on solid organ histological characteristics
dc.typeArtículos de revistas


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