Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

dc.creatorOliveira, Jaqueline Carvalho de
dc.creatorScrideli, Carlos Alberto
dc.creatorAnnichini, Maria Sol Brassesco
dc.creatorMorales, Andressa Gois
dc.creatorPezuk, Julia Alejandra
dc.creatorQueiroz, Rosane Gomes de Paula
dc.creatorYunes, Jose Andres
dc.creatorBrandalise, Silvia Regina
dc.creatorTone, Luiz Gonzaga
dc.date.accessioned2013-11-04T14:18:03Z
dc.date.accessioned2018-07-04T16:10:44Z
dc.date.available2013-11-04T14:18:03Z
dc.date.available2018-07-04T16:10:44Z
dc.date.created2013-11-04T14:18:03Z
dc.date.issued2012
dc.identifierLEUKEMIA RESEARCH, OXFORD, v. 36, n. 3, supl. 1, Part 3, pp. 293-298, MAR, 2012
dc.identifier0145-2126
dc.identifierhttp://www.producao.usp.br/handle/BDPI/40806
dc.identifier10.1016/j.leukres.2011.10.005
dc.identifierhttp://dx.doi.org/10.1016/j.leukres.2011.10.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1632461
dc.description.abstractThe present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.publisherOXFORD
dc.relationLEUKEMIA RESEARCH
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsclosedAccess
dc.subjectMICRORNA
dc.subjectPEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA
dc.subjectPROGNOSTIC FEATURES
dc.titleDifferential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
dc.typeArtículos de revistas


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