dc.creatorDrobyshevsky, Alexander
dc.creatorDerrick, Matthew
dc.creatorLuo, Kehuan
dc.creatorZhang, Li-Qun
dc.creatorWu, Yi-Ning
dc.creatorTakada, Silvia Honda
dc.creatorYu, Lei
dc.creatorTan, Sidhartha
dc.date.accessioned2013-11-01T15:12:37Z
dc.date.accessioned2018-07-04T16:10:06Z
dc.date.available2013-11-01T15:12:37Z
dc.date.available2018-07-04T16:10:06Z
dc.date.created2013-11-01T15:12:37Z
dc.date.issued2012
dc.identifierSTROKE, PHILADELPHIA, v. 43, n. 10, supl. 1, Part 3, pp. 2757-+, OCT, 2012
dc.identifier0039-2499
dc.identifierhttp://www.producao.usp.br/handle/BDPI/37548
dc.identifier10.1161/STROKEAHA.112.653857
dc.identifierhttp://dx.doi.org/10.1161/STROKEAHA.112.653857
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1632320
dc.description.abstractBackground and Purpose-The pattern of antenatal brain injury varies with gestational age at the time of insult. Deep brain nuclei are often injured at older gestational ages. Having previously shown postnatal hypertonia after preterm fetal rabbit hypoxia-ischemia, the objective of this study was to investigate the causal relationship between the dynamic regional pattern of brain injury on MRI and the evolution of muscle tone in the near-term rabbit fetus. Methods-Serial MRI was performed on New Zealand white rabbit fetuses to determine equipotency of fetal hypoxia-ischemia during uterine ischemia comparing 29 days gestation (E29, 92% gestation) with E22 and E25. E29 postnatal kits at 4, 24, and 72 hours after hypoxia-ischemia underwent T2- and diffusion-weighted imaging. Quantitative assessments of tone were made serially using a torque apparatus in addition to clinical assessments. Results-Based on the brain apparent diffusion coefficient, 32 minutes of uterine ischemia was selected for E29 fetuses. At E30, 58% of the survivors manifested hind limb hypotonia. By E32, 71% of the hypotonic kits developed dystonic hypertonia. Marked and persistent apparent diffusion coefficient reduction in the basal ganglia, thalamus, and brain stem was predictive of these motor deficits. Conclusions-MRI observation of deep brain injury 6 to 24 hours after near-term hypoxia-ischemia predicts dystonic hypertonia postnatally. Torque-displacement measurements indicate that motor deficits in rabbits progressed from initial hypotonia to hypertonia, similar to human cerebral palsy, but in a compressed timeframe. The presence of deep brain injury and quantitative shift from hypo-to hypertonia may identify patients at risk for developing cerebral palsy. (Stroke. 2012;43:2757-2763.)
dc.languageeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.publisherPHILADELPHIA
dc.relationSTROKE
dc.rightsCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.rightsclosedAccess
dc.subjectDIFFUSION-WEIGHTED IMAGING
dc.subjectHYPERTONIA
dc.subjectHYPOXIC-ISCHEMIC ENCEPHALOPATHY
dc.titleNear-Term Fetal Hypoxia-Ischemia in Rabbits MRI Can Predict Muscle Tone Abnormalities and Deep Brain Injury
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución