Artículos de revistas
Antioxidant capacity and environmentally friendly synthesis of dihydropyrimidin-(2H)-ones promoted by naturally occurring organic acids
Fecha
2012Registro en:
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, MALDEN, v. 26, n. 4, p. 155-161, MAR-APR, 2012
1095-6670
10.1002/jbt.20424
Autor
Vasconcelos, Alana de
Oliveira, Pathise S.
Ritter, Marina
Freitag, Rogerio A.
Romano, Renato L.
Quina, Frank Herbert
Pizzuti, Lucas
Pereira, Claudio M. P.
Stefanello, Francieli M.
Barschak, Alethea G.
Institución
Resumen
The Biginelli reaction is a multicomponent reaction involving the condensation between an aldehyde, a beta-ketoester, and urea or thiourea, in the presence of an acid catalyst, producing dihydropyrimidinones (DHPMs). Owing to their important pharmacological properties, the DHPMs have been studied by many authors. However, most of the methodologies used for the synthesis of these compounds require drastic reaction conditions. In the current study, we report an efficient and clean procedure for preparing DHPMs by the use of citric acid or tartaric acid as a promoter of the Biginelli synthesis in ethanol as solvent. In addition, we have evaluated the antioxidant capacity of the compounds synthesized by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and the thiobarbituric acid-reactive species test. Two compounds presented antioxidant activity and also reduced lipid peroxidation at concentrations of 200 and 300 mu M. In summary, we report an environmentally friendly procedure for the preparation of DHPMs and demonstrate the antioxidant capacity of some of the compounds. (C) 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:155161, 2012; View this article online at . DOI 10.1002/jbt.20424