Artículos de revistas
The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates
Fecha
2012Registro en:
FOOD AND CHEMICAL TOXICOLOGY, OXFORD, v. 50, n. 12, supl. 1, Part 3, pp. 4412-4420, DEC, 2012
0278-6915
10.1016/j.fct.2012.09.002
Autor
Leal, Mariana Ferreira
Greggi Antunes, Lusania Maria
Vita Lamarao, Maria Fernanda
Araujo da Silva, Carla Elvira
Cotrim Guerreiro da Silva, Ismael Dale
Assumpcao, Paulo Pimentel
Andrade, Edilson Ferreira
Rezende, Alexandre Pingarilho
Imbeloni, Aline Amaral
Pereira Carneiro Muniz, Jose Augusto
Pinto, Giovanny Reboucas
Cardoso Smith, Marilia de Arruda
Burbano, Rommel Rodriguez
Institución
Resumen
Background: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates. Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40 days. Micronucleus and comet assays were performed for the evaluation of DNA damage. Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. The frequency of these alterations was significantly lower in the Canova group than in the group without this medicine. Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella. (C) 2012 Elsevier Ltd. All rights reserved.