dc.creator | Felippotti, Tatiana Tocchini | |
dc.creator | Freitas, Renato Leonardo de | |
dc.creator | Coimbra, Norberto Cysne | |
dc.date.accessioned | 2013-10-25T11:30:04Z | |
dc.date.accessioned | 2018-07-04T16:01:27Z | |
dc.date.available | 2013-10-25T11:30:04Z | |
dc.date.available | 2018-07-04T16:01:27Z | |
dc.date.created | 2013-10-25T11:30:04Z | |
dc.date.issued | 2012-02 | |
dc.identifier | NEUROPEPTIDES, EDINBURGH, v. 46, n. 1, pp. 39-47, FEB, 2012 | |
dc.identifier | 0143-4179 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/36045 | |
dc.identifier | 10.1016/j.npep.2011.10.001 | |
dc.identifier | http://dx.doi.org/10.1016/j.npep.2011.10.001 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1630592 | |
dc.description.abstract | Background: The aim of the present work was to investigate the involvement of the mu(1)-endogenous opioid peptide receptor-mediated system in post-ictal antinociception. Methods: Antinociceptive responses were determined by the tail-flick test after pre-treatment with the selective mu(1)-opioid receptor antagonist naloxonazine, peripherally or centrally administered at different doses. Results: Peripheral subchronic (24 h) pre-treatment with naloxonazine antagonised the antinociception elicited by tonic-clonic seizures. Acute (10 min) pre-treatment, however, did not have the same effect. In addition, microinjections of naloxonazine into the central, dorsal cortical and external cortical nuclei of the inferior colliculus antagonised tonic-clonic seizure-induced antinociception. Neither acute (10-min) peripheral pre-treatment with naloxonazine nor subchronic intramesencephalic blockade of mu(1)-opioid receptors resulted in consistent statistically significant differences in the severity of tonic-clonic seizures shown by Racine's index (1972), although the intracollicular specific antagonism of mu(1)-opioid receptor decreased the duration of seizures. Conclusion: mu(1)-Opioid receptors and the inferior colliculus have been implicated in several endogenous opioid peptide-mediated responses such as antinociception and convulsion. The present findings suggest the involvement of mu(1)-opiate receptors of central and pericentral nuclei of the inferior colliculus in the modulation of tonic-clonic seizures and in the organisation of post-ictal antinociception. (C) 2011 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | CHURCHILL LIVINGSTONE | |
dc.publisher | EDINBURGH | |
dc.relation | Neuropeptides | |
dc.rights | Copyright CHURCHILL LIVINGSTONE | |
dc.rights | closedAccess | |
dc.subject | NALOXONAZINE | |
dc.subject | MU(1)-OPIOID RECEPTORS | |
dc.subject | POST-ICTAL ANALGESIA | |
dc.subject | INFERIOR COLLICULUS | |
dc.title | Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits mu(1)-opioid receptor to modulate post-ictal antinociception | |
dc.type | Artículos de revistas | |