dc.creatorMiyabara, Elen Haruka
dc.creatorNascimento, Tábata Leal
dc.creatorRodrigues, Debora C.
dc.creatorMoriscot, Anselmo Sigari
dc.creatorDavila, Wilmer F.
dc.creatorAitMou, Younss
dc.creatordeTombe, Pieter P.
dc.creatorMestril, Ruben
dc.date.accessioned2013-10-24T10:25:50Z
dc.date.accessioned2018-07-04T16:01:00Z
dc.date.available2013-10-24T10:25:50Z
dc.date.available2018-07-04T16:01:00Z
dc.date.created2013-10-24T10:25:50Z
dc.date.issued2012
dc.identifierPFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, NEW YORK, v. 463, n. 5, supl. 4, Part 1, pp. 733-741, MAY, 2012
dc.identifier0031-6768
dc.identifierhttp://www.producao.usp.br/handle/BDPI/35803
dc.identifier10.1007/s00424-012-1087-x
dc.identifierhttp://dx.doi.org/10.1007/s00424-012-1087-x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1630498
dc.description.abstractHeat shock proteins play a key regulatory role in cellular defense. To investigate the role of the inducible 70-kDa heat shock protein (HSP70) in skeletal muscle atrophy and subsequent recovery, soleus (SOL) and extensor digitorum longus (EDL) muscles from overexpressing HSP70 transgenic mice were immobilized for 7 days and subsequently released from immobilization and evaluated after 7 days. Histological analysis showed that there was a decrease in cross-sectional area of type II myofiber from EDL and types I and II myofiber from SOL muscles at 7-day immobilization in both wild-type and HSP70 mice. At 7-day recovery, EDL and SOL myofibers from HSP70 mice, but not from wild-type mice, recovered their size. Muscle tetanic contraction decreased only in SOL muscles from wild-type mice at both 7-day immobilization and 7-day recovery; however, it was unaltered in the respective groups from HSP70 mice. Although no effect in a fatigue protocol was observed among groups, we noticed a better contractile performance of EDL muscles from overexpressing HSP70 groups as compared to their matched wild-type groups. The number of NCAM positive-satellite cells reduced after immobilization and recovery in both EDL and SOL muscles from wild-type mice, but it was unchanged in the muscles from HSP70 mice. These results suggest that HSP70 improves structural and functional recovery of skeletal muscle after disuse atrophy, and this effect might be associated with preservation of satellite cell amount.
dc.languageeng
dc.publisherSPRINGER
dc.publisherNEW YORK
dc.relationPFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
dc.rightsCopyright SPRINGER
dc.rightsclosedAccess
dc.subjectMUSCLE ATROPHY
dc.subjectHEAT SHOCK PROTEIN
dc.subjectTRANSGENIC MOUSE
dc.subjectFORCE PRODUCTION
dc.subjectMYOFIBER MASS RECOVERY
dc.titleOverexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy
dc.typeArtículos de revistas


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