Artículos de revistas
Fc gamma Receptor Gene Polymorphisms in Childhood Immune Thrombocytopenic Purpura
Fecha
2012Registro en:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, PHILADELPHIA, v. 34, n. 5, supl. 1, Part 4, pp. 349-352, JUL, 2012
1077-4114
10.1097/MPH.0b013e3182580908
Autor
de Mendonca Caldas Amorim, Daniela Maria
Silveira, Vanessa da Silva
Scrideli, Carlos Alberto
de Paula Queiroz, Rosane Gomes
Tone, Luiz Gonzaga
Institución
Resumen
Immune thrombocytopenic purpura (ITP) is a common hematological disorder in the childhood, and it is one of the most common forms of autoimmune disease in pediatric patients. The ITP basis is a primary dysfunction of the immune system. This study aimed to analyze the genetic polymorphisms of the Fc gamma receptors IIA and IIIA. The genetic polymorphisms of the Fc receptors gamma IIA (131H/R) and gamma RIIIA (158V/F) were analyzed by polymerase chain reaction-restriction fragment length polymorphism technique. Odds ratio and 95% confidence interval were calculated by chi(2) test. Homozygous polymorphic genotype for the Fc gamma RIIIA was significantly more frequent among patients compared with controls (odds ratio = 0.27; 95% confidence interval, 0.09-0.80; P = 0.03). There was no statistical difference between the ITP group and the controls in the analysis of combinations of alleles of the high-affinity Fc receptor, but the ITP individuals with this combination had a lower duration of disease (P = 0.01). Genetic polymorphisms in immune system genes can be important for ITP pathogenesis and disease outcome.