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DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
| dc.creator | de Lima Gomes, Elionai Cassiana | |
| dc.creator | Cunha Junior, Armando da Silva | |
| dc.creator | Yoshida, Maria Irene | |
| dc.creator | Jorge, Rodrigo | |
| dc.date.accessioned | 2013-10-12T19:15:10Z | |
| dc.date.accessioned | 2018-07-04T15:59:48Z | |
| dc.date.available | 2013-10-12T19:15:10Z | |
| dc.date.available | 2018-07-04T15:59:48Z | |
| dc.date.created | 2013-10-12T19:15:10Z | |
| dc.date.issued | 2012 | |
| dc.identifier | QUIMICA NOVA, SAO PAULO, v. 35, n. 3, supl. 18, Part 2, pp. 608-611, MAY, 2012 | |
| dc.identifier | 0100-4042 | |
| dc.identifier | http://www.producao.usp.br/handle/BDPI/34260 | |
| dc.identifier | 10.1590/S0100-40422012000300029 | |
| dc.identifier | http://dx.doi.org/10.1590/S0100-40422012000300029 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1630227 | |
| dc.description.abstract | DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin (R)) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250 (R) HR SEC, 300 x 7.8 mm x 5 mu m (Waters, USA). The mobile phase consisted of phosphate buffered saline (PBS). The results revealed that the method was specific, precise. accurate, robust and linear (r(2) = 0.998) from 5 to 75 mu g mL(-1). Therefore, this method can be used in drug release studies or in quality control ampoules of the drug. | |
| dc.language | por | |
| dc.publisher | SOC BRASILEIRA QUIMICA | |
| dc.publisher | SAO PAULO | |
| dc.relation | QUIMICA NOVA | |
| dc.rights | Copyright SOC BRASILEIRA QUIMICA | |
| dc.rights | openAccess | |
| dc.subject | BEVACIZUMAB | |
| dc.subject | HIGH PERFORMANCE LIQUID CHROMATOGRAPHY | |
| dc.subject | VALIDATION | |
| dc.title | DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY | |
| dc.type | Artículos de revistas |