DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

dc.creatorde Lima Gomes, Elionai Cassiana
dc.creatorCunha Junior, Armando da Silva
dc.creatorYoshida, Maria Irene
dc.creatorJorge, Rodrigo
dc.date.accessioned2013-10-12T19:15:10Z
dc.date.accessioned2018-07-04T15:59:48Z
dc.date.available2013-10-12T19:15:10Z
dc.date.available2018-07-04T15:59:48Z
dc.date.created2013-10-12T19:15:10Z
dc.date.issued2012
dc.identifierQUIMICA NOVA, SAO PAULO, v. 35, n. 3, supl. 18, Part 2, pp. 608-611, MAY, 2012
dc.identifier0100-4042
dc.identifierhttp://www.producao.usp.br/handle/BDPI/34260
dc.identifier10.1590/S0100-40422012000300029 
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422012000300029 
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1630227
dc.description.abstractDEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin (R)) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250 (R) HR SEC, 300 x 7.8 mm x 5 mu m (Waters, USA). The mobile phase consisted of phosphate buffered saline (PBS). The results revealed that the method was specific, precise. accurate, robust and linear (r(2) = 0.998) from 5 to 75 mu g mL(-1). Therefore, this method can be used in drug release studies or in quality control ampoules of the drug.
dc.languagepor
dc.publisherSOC BRASILEIRA QUIMICA
dc.publisherSAO PAULO
dc.relationQUIMICA NOVA
dc.rightsCopyright SOC BRASILEIRA QUIMICA
dc.rightsopenAccess
dc.subjectBEVACIZUMAB
dc.subjectHIGH PERFORMANCE LIQUID CHROMATOGRAPHY
dc.subjectVALIDATION
dc.titleDEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución