dc.creatorSchatz, Andreas
dc.creatorWilke, Robert
dc.creatorStrasser, Torsten
dc.creatorGekeler, Florian
dc.creatorMessias, Andre
dc.creatorZrenner, Eberhart
dc.date.accessioned2013-10-22T10:14:02Z
dc.date.accessioned2018-07-04T15:59:41Z
dc.date.available2013-10-22T10:14:02Z
dc.date.available2018-07-04T15:59:41Z
dc.date.created2013-10-22T10:14:02Z
dc.date.issued2012
dc.identifierDOCUMENTA OPHTHALMOLOGICA, DORDRECHT, v. 124, n. 1, supl. 4, Part 1, pp. 27-39, FEB, 2012
dc.identifier0012-4486
dc.identifierhttp://www.producao.usp.br/handle/BDPI/35445
dc.identifier10.1007/s10633-011-9302-1
dc.identifierhttp://dx.doi.org/10.1007/s10633-011-9302-1
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1630198
dc.description.abstractTo refine methods of electroretinographical (ERG) recording for the analysis of low retinal potentials under scotopic conditions in advanced retinal degenerative diseases. Standard Ganzfeld ERG equipment (Diagnosys LLC, Cambridge, UK) was used in 27 healthy volunteers (mean age 28 +/- A SD 8.5 years) to define the stimulation protocol. The protocol was then applied in clinical routine and 992 recordings were obtained from patients (mean age 40.6 +/- A 18.3 years) over a period of 5 years. A blue stimulus with a flicker frequency of 9 Hz was specified under scotopic conditions to preferentially record rod-driven responses. A range of stimulus strengths (0.0000012-6.32 scot. cd s/mA(2) and 6-14 ms flash duration) was tested for maximal amplitudes and interference between rods and cones. Analysis of results was done by standard Fourier Transformation and assessment of signal-to-noise ratio. Optimized stimulus parameters were found to be a time-integrated luminance of 0.012 scot. cd s/mA(2) using a blue (470 nm) flash of 10 ms duration at a repetition frequency of 9 Hz. Characteristic stimulus strength versus amplitude curves and tests with stimuli of red or green wavelength suggest a predominant rod-system response. The 9 Hz response was found statistically distinguishable from noise in 38% of patients with otherwise non-recordable rod responses according to International Society for Clinical Electrophysiology of Vision standards. Thus, we believe this protocol can be used to record ERG potentials in patients with advanced retinal diseases and in the evaluation of potential treatments for these patients. The ease of implementation in clinical routine and of statistical evaluation providing an observer-independent evaluation may further facilitate its employment.
dc.languageeng
dc.publisherSPRINGER
dc.publisherDORDRECHT
dc.relationDOCUMENTA OPHTHALMOLOGICA
dc.rightsCopyright SPRINGER
dc.rightsclosedAccess
dc.subjectELECTRORETINOGRAPHY
dc.subjectDEGENERATION
dc.subjectRESIDUAL FUNCTION
dc.subjectSUB-MICROVOLT RESPONSES
dc.subjectTHERAPY MARKER
dc.subjectRETINITIS PIGMENTOSA
dc.titleAssessment of "non-recordable" electroretinograms by 9 Hz flicker stimulation under scotopic conditions
dc.typeArtículos de revistas


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