dc.creatorFerreira, Leandro De Santis
dc.creatorCallejon, Daniel Roberto
dc.creatorEngemann, Anna
dc.creatorCramer, Benedikt
dc.creatorHumpf, Hans-Ulrich
dc.creatorBarros, Valeria Priscila de
dc.creatorAssis, Marilda das Dores
dc.creatorSilva, Denise Brentan da
dc.creatorAlbuquerque, Sérgio de
dc.creatorOkano, Laura Tiemi
dc.creatorKato, Massuo Jorge
dc.creatorLopes, Norberto Peporine
dc.date.accessioned2013-09-26T12:34:15Z
dc.date.accessioned2018-07-04T15:57:35Z
dc.date.available2013-09-26T12:34:15Z
dc.date.available2018-07-04T15:57:35Z
dc.date.created2013-09-26T12:34:15Z
dc.date.issued2012-12
dc.identifierPLANTA MEDICA, STUTTGART, v. 78, n. 18, pp. 1939-1941, DEC, 2012
dc.identifier0032-0943
dc.identifierhttp://www.producao.usp.br/handle/BDPI/33742
dc.identifier10.1055/s-0032-1327876
dc.identifierhttp://dx.doi.org/10.1055/s-0032-1327876
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1629728
dc.description.abstractTetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi. In this work, the in vitro metabolism of grandisin was studied in the pig cecum model and by biomimetic phase I reactions, aiming at an ensuing a preclinical pharmacokinetic investigation. Although grandisin exhibited no metabolization by the pig microbiota, one putative metabolite was formed in a biomimetic model using Jacobsen catalyst. The putative metabolite was tested against T. cruzi revealing loss of activity in comparison to grandisin.
dc.languageeng
dc.publisherGEORG THIEME VERLAG KG
dc.publisherSTUTTGART
dc.relationPLANTA MEDICA
dc.rightsCopyright GEORG THIEME VERLAG KG
dc.rightsopenAccess
dc.subjectTETRAHYDROFURAN LIGNANS
dc.subjectGRANDISIN
dc.subjectIN VITRO METABOLISM
dc.subjectPIPER SOLMSIANUM
dc.subjectPIPERACEAE
dc.subjectJACOBSEN CATALYST
dc.titleIn vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity
dc.typeArtículos de revistas


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