dc.creator | Ferreira, Leandro De Santis | |
dc.creator | Callejon, Daniel Roberto | |
dc.creator | Engemann, Anna | |
dc.creator | Cramer, Benedikt | |
dc.creator | Humpf, Hans-Ulrich | |
dc.creator | Barros, Valeria Priscila de | |
dc.creator | Assis, Marilda das Dores | |
dc.creator | Silva, Denise Brentan da | |
dc.creator | Albuquerque, Sérgio de | |
dc.creator | Okano, Laura Tiemi | |
dc.creator | Kato, Massuo Jorge | |
dc.creator | Lopes, Norberto Peporine | |
dc.date.accessioned | 2013-09-26T12:34:15Z | |
dc.date.accessioned | 2018-07-04T15:57:35Z | |
dc.date.available | 2013-09-26T12:34:15Z | |
dc.date.available | 2018-07-04T15:57:35Z | |
dc.date.created | 2013-09-26T12:34:15Z | |
dc.date.issued | 2012-12 | |
dc.identifier | PLANTA MEDICA, STUTTGART, v. 78, n. 18, pp. 1939-1941, DEC, 2012 | |
dc.identifier | 0032-0943 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/33742 | |
dc.identifier | 10.1055/s-0032-1327876 | |
dc.identifier | http://dx.doi.org/10.1055/s-0032-1327876 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1629728 | |
dc.description.abstract | Tetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi. In this work, the in vitro metabolism of grandisin was studied in the pig cecum model and by biomimetic phase I reactions, aiming at an ensuing a preclinical pharmacokinetic investigation. Although grandisin exhibited no metabolization by the pig microbiota, one putative metabolite was formed in a biomimetic model using Jacobsen catalyst. The putative metabolite was tested against T. cruzi revealing loss of activity in comparison to grandisin. | |
dc.language | eng | |
dc.publisher | GEORG THIEME VERLAG KG | |
dc.publisher | STUTTGART | |
dc.relation | PLANTA MEDICA | |
dc.rights | Copyright GEORG THIEME VERLAG KG | |
dc.rights | openAccess | |
dc.subject | TETRAHYDROFURAN LIGNANS | |
dc.subject | GRANDISIN | |
dc.subject | IN VITRO METABOLISM | |
dc.subject | PIPER SOLMSIANUM | |
dc.subject | PIPERACEAE | |
dc.subject | JACOBSEN CATALYST | |
dc.title | In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity | |
dc.type | Artículos de revistas | |