dc.creator | Ramalhete, Catia | |
dc.creator | Magalhaes, Lizandra G. | |
dc.creator | Rodrigues, Vanderlei | |
dc.creator | Mulhovo, Silva | |
dc.creator | Da Silva Filho, Ademar A. | |
dc.creator | Ferreira, Maria-Jose U. | |
dc.date.accessioned | 2013-10-12T16:41:34Z | |
dc.date.accessioned | 2018-07-04T15:56:37Z | |
dc.date.available | 2013-10-12T16:41:34Z | |
dc.date.available | 2018-07-04T15:56:37Z | |
dc.date.created | 2013-10-12T16:41:34Z | |
dc.date.issued | 2012 | |
dc.identifier | PLANTA MEDICA, STUTTGART, v. 78, n. 18, supl. 4, Part 1, pp. 1912-1917, DEC, 2012 | |
dc.identifier | 0032-0943 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/34193 | |
dc.identifier | 10.1055/s-0032-1327832 | |
dc.identifier | http://dx.doi.org/10.1055/s-0032-1327832 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1629504 | |
dc.description.abstract | Five cucurbitane-type triterpenes (1-5), previously isolated from the African medicinal plant Momordica balsamina, along with five ester derivatives (6-10) of karavilagenin C (2), were evaluated for their potential schistosomicidal activity against Schistosoma mansoni adult worms. The natural compounds were isolated from the ethyl acetate-soluble fraction of the methanol extract of the aerial parts of M. balsamina. In a preliminary study, a significant schistosomicidal activity was observed for both the crude methanol extract and the ethyl acetate fraction. The compounds responsible for the activity were found to be balsaminol F (1) and karavilagenin C (2) with LC50 values of 14.7 +/- 1.5 and 28.9 +/- 1.8 mu M, respectively, after 24 h of incubation (positive control praziquantel, LC50 = 1.2 +/- 0.1 mu M). Both compounds (1, 2), at 10-50 mu M, induced significant reductions in the motor activity of the worms and significantly decreased the egg production. Furthermore, they were able (at 10-100 mu M) to separate the adult worm pairs into male and female after 24 h. Compounds 3-5, bearing a sugar moiety as a substituent, and the acylated derivatives of karavilagenin C (6-10) were inactive, suggesting that the presence of free hydroxyl groups in the tetracyclic skeleton might be important for the activity. A correlation between activity and the molecular volume/weight of compounds was also found. | |
dc.language | eng | |
dc.publisher | GEORG THIEME VERLAG KG | |
dc.publisher | STUTTGART | |
dc.relation | PLANTA MEDICA | |
dc.rights | Copyright GEORG THIEME VERLAG KG | |
dc.rights | closedAccess | |
dc.subject | SCHISTOSOMICIDAL ACTIVITY | |
dc.subject | SCHISTOSOMA MANSONI | |
dc.subject | MOMORDICA BALSAMINA | |
dc.subject | CUCURBITACEAE | |
dc.subject | CUCURBITANE-TYPE TRITERPENOIDS | |
dc.title | In Vitro Schistosomicidal Activity of Balsaminol F and Karavilagenin C | |
dc.type | Artículos de revistas | |