Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium tuberculosis activity and cytotoxicity

dc.creatorPAVAN, Fernando R.
dc.creatorMAIA, Pedro I. da S.
dc.creatorLEITE, Sergio R. A.
dc.creatorDEFLON, Victor M.
dc.creatorBATISTA, Alzir A.
dc.creatorSATO, Daisy N.
dc.creatorFRANZBLAU, Scott G.
dc.creatorLEITE, Clarice Q. F.
dc.date.accessioned2012-10-20T05:33:59Z
dc.date.accessioned2018-07-04T15:51:52Z
dc.date.available2012-10-20T05:33:59Z
dc.date.available2018-07-04T15:51:52Z
dc.date.created2012-10-20T05:33:59Z
dc.date.issued2010
dc.identifierEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, n.5, p.1898-1905, 2010
dc.identifier0223-5234
dc.identifierhttp://producao.usp.br/handle/BDPI/31809
dc.identifier10.1016/j.ejmech.2010.01.028
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2010.01.028
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1628447
dc.description.abstractThe aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithio-carbazates and hydrazide/hydrazones compounds. The minimal inhibitory concentration (MIC) of these compounds against Mycobacterium tuberculosis was determined. Their in vitro cytotoxicity to J774 cells (IC(50)) was determined to establish a selectivity index (SI) (SI = IC(50)/MIC). The best compounds were the thiosemicarbazones (2, 3 and 4) and the hydrazide/hydrazones (14, 15, 16 and 18). The results are comparable to or better than those of ""first line"" or ""second line"" drugs commonly used to treat TB, suggesting these compounds as anti-TB drug candidates. (C) 2010 Elsevier Masson SAS. All rights reserved.
dc.languageeng
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
dc.relationEuropean Journal of Medicinal Chemistry
dc.rightsCopyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
dc.rightsrestrictedAccess
dc.subjectAntimycobacterial agents
dc.subjectREMA
dc.subjectCytotoxicity
dc.subjectThiosemicarbazones
dc.subjectSemicarbazones
dc.subjectDithiocarbazates
dc.subjectHydrazide/hydrazones
dc.titleThiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium tuberculosis activity and cytotoxicity
dc.typeArtículos de revistas


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