THE POTENTIALITIES OF USING A GRAPHITE-SILICONE RUBBER COMPOSITE ELECTRODE IN THE DETERMINATION OF PROPRANOLOL

dc.creatorSANTOS, Sidney Xavier dos
dc.creatorCAVALHEIRO, Eder Tadeu Gomes
dc.date.accessioned2012-10-20T05:33:51Z
dc.date.accessioned2018-07-04T15:51:45Z
dc.date.available2012-10-20T05:33:51Z
dc.date.available2018-07-04T15:51:45Z
dc.date.created2012-10-20T05:33:51Z
dc.date.issued2011
dc.identifierANALYTICAL LETTERS, v.44, n.5, p.850-862, 2011
dc.identifier0003-2719
dc.identifierhttp://producao.usp.br/handle/BDPI/31788
dc.identifier10.1080/00032711003789991
dc.identifierhttp://dx.doi.org/10.1080/00032711003789991
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1628426
dc.description.abstractA graphite silicone-rubber composite electrode (GSR) was used for the determination of propranolol in drug formulation. Cyclic voltammetry (CV) at the GSR presented an irreversible oxidation peak at + 0.8V vs. SCE, in Britton Robinson (B-R) buffer pH 7.4. The quantitative determination was carried out using differential pulse voltammetry (DPV). Under optimized parameters a linear dynamic range from 5.0 to 80.6 mu mol L(-1) with a detection limit of 1.1 mu mol L(-1) was observed. A repeatability of 4.5 +/- 0.1 mu A (n = 10) peak current was found after 10 successive DPV voltammograms of propranolol in the same solution after surface renovations. Using the proposed electrode, propranolol was quantified in a pharmaceutical formulation with results that agreed within 95% confidence level (t-test) with those from an official method.
dc.languageeng
dc.publisherTAYLOR & FRANCIS INC
dc.relationAnalytical Letters
dc.rightsCopyright TAYLOR & FRANCIS INC
dc.rightsrestrictedAccess
dc.subjectComposite electrodes
dc.subjectPropranolol
dc.subjectSilicone-rubber
dc.titleTHE POTENTIALITIES OF USING A GRAPHITE-SILICONE RUBBER COMPOSITE ELECTRODE IN THE DETERMINATION OF PROPRANOLOL
dc.typeArtículos de revistas


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