Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)

dc.creatorOTELO, Vanessa A.
dc.creatorSANT`ANA, Antonio C.
dc.creatorFARIA, Dalva L. A. de
dc.creatorMENEZES, Carla M. S.
dc.date.accessioned2012-10-20T05:24:41Z
dc.date.accessioned2018-07-04T15:50:15Z
dc.date.available2012-10-20T05:24:41Z
dc.date.available2018-07-04T15:50:15Z
dc.date.created2012-10-20T05:24:41Z
dc.date.issued2011
dc.identifierBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, n.1, p.250-254, 2011
dc.identifier0960-894X
dc.identifierhttp://producao.usp.br/handle/BDPI/31431
dc.identifier10.1016/j.bmcl.2010.11.019
dc.identifierhttp://dx.doi.org/10.1016/j.bmcl.2010.11.019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1628069
dc.description.abstractReversed chloroquine (RCQ) is a multiple ligand compound active against chloroquine-sensitive and resistant falciparum malaria. It is composed by a 4-aminoquinoline moiety (like that present in chloroquine (CQ)) joined to imipramine (IMP), a modulating agent that also showed intrinsic antiplasmodial activity against Brazilian Plasmodium falciparum isolates resistant to CQ. Molecular modeling and ultraviolet-visible spectroscopy (UV-vis) studies strongly suggest that the interaction between RCQ and heme is predominant through the quinoline moiety in a mechanism of action similar to that observed for CQ. (C) 2010 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationBioorganic & Medicinal Chemistry Letters
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectReversed chloroquine
dc.subjectChloroquine
dc.subjectHeme
dc.subjectAntimalarial
dc.subjectMultiple ligand
dc.titleMolecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)
dc.typeArtículos de revistas


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