Trypanocidal tetrahydrofuran lignans from Peperomia blanda

dc.creatorFELIPPE, Lidiane Gaspareto
dc.creatorBALDOQUI, Debora Cristina
dc.creatorKATO, Massuo Jorge
dc.creatorBOLZANI, Vanderlan da Silva
dc.creatorGUIMARAES, Elsie Franklin
dc.creatorCICARELLI, Regina Maria Barreto
dc.creatorFURLAN, Maysa
dc.date.accessioned2012-10-20T05:24:16Z
dc.date.accessioned2018-07-04T15:49:53Z
dc.date.available2012-10-20T05:24:16Z
dc.date.available2018-07-04T15:49:53Z
dc.date.created2012-10-20T05:24:16Z
dc.date.issued2008
dc.identifierPHYTOCHEMISTRY, v.69, n.2, p.445-450, 2008
dc.identifier0031-9422
dc.identifierhttp://producao.usp.br/handle/BDPI/31357
dc.identifier10.1016/j.phytochem.2007.08.012
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2007.08.012
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1627995
dc.description.abstractFive tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastercomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y. (C) 2007 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationPhytochemistry
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectPeperomia blanda
dc.subjectPiperaceae
dc.subjecttetrahydrofuran lignans
dc.subjectstructural elucidation
dc.subjecttrypanocidal activity
dc.titleTrypanocidal tetrahydrofuran lignans from Peperomia blanda
dc.typeArtículos de revistas


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