A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system

dc.creatorCHUDZINSKI-TAVASSI, Ana Marisa
dc.creatorDE-SA-JUNIOR, Paulo Luis
dc.creatorSIMONS, Simone Michaela
dc.creatorMARIA, Durvanei Augusto
dc.creatorVENTURA, Janaina de Souza
dc.creatorBATISTA, Isabel de Fatima Correia
dc.creatorFARIA, Fernanda
dc.creatorDURAES, Esther
dc.creatorREIS, Eduardo Moraes
dc.creatorDEMASI, Marilene
dc.date.accessioned2012-10-20T05:20:59Z
dc.date.accessioned2018-07-04T15:48:11Z
dc.date.available2012-10-20T05:20:59Z
dc.date.available2018-07-04T15:48:11Z
dc.date.created2012-10-20T05:20:59Z
dc.date.issued2010
dc.identifierTOXICON, v.56, n.7, Special Issue, p.1145-1154, 2010
dc.identifier0041-0101
dc.identifierhttp://producao.usp.br/handle/BDPI/30948
dc.identifier10.1016/j.toxicon.2010.04.019
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.04.019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1627587
dc.description.abstractThe aim of this study was to evaluate the anti-tumor activity of Amblyomin-X, a serine protease Kunitz-type inhibitor. Amblyomin-X induced tumor mass regression and decreased number of metastatic events in a B16F10 murine melanoma model. Alterations on expression of several genes related to cell cycle were observed when two tumor cell lines were treated with Amblyomin-X. PSMB2, which encodes a proteasome subunit, was differentially expressed, in agreement to inhibition of proteasomal activity in both cell lines. In conclusion, our results indicate that Amblyomin-X selectively acts on tumor cells by inducing apoptotic cell death, possibly by targeting the ubiquitin-proteasome system. (C) 2010 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationToxicon
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectApoptosis
dc.subjectProteasome inhibition
dc.subjectAmblyomin-X
dc.subjectTick
dc.subjectAmblyomma cajennense
dc.titleA new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system
dc.typeArtículos de revistas


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