dc.creator | TEIXEIRA, Roberto Augusto Plaza | |
dc.creator | ODONE-FILHO, Vicente | |
dc.creator | CAMARGO, Beatriz de | |
dc.creator | ZERBINI, Maria Claudia | |
dc.creator | FILLIPI, Renne | |
dc.creator | ALENCAR, Arlaine | |
dc.creator | CRISTOFANI, Lilian | |
dc.date.accessioned | 2012-10-20T04:44:10Z | |
dc.date.accessioned | 2018-07-04T15:46:02Z | |
dc.date.available | 2012-10-20T04:44:10Z | |
dc.date.available | 2018-07-04T15:46:02Z | |
dc.date.created | 2012-10-20T04:44:10Z | |
dc.date.issued | 2011 | |
dc.identifier | PEDIATRIC HEMATOLOGY AND ONCOLOGY, v.28, n.3, p.194-202, 2011 | |
dc.identifier | 0888-0018 | |
dc.identifier | http://producao.usp.br/handle/BDPI/30442 | |
dc.identifier | 10.3109/08880018.2010.533250 | |
dc.identifier | http://dx.doi.org/10.3109/08880018.2010.533250 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1627081 | |
dc.description.abstract | Fifteen percent of patients with Wilms`` tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. The authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight >= a parts per thousand yen550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%%) of the patients, of which 10/12 (83.3%%) relapsed and 8/28 (28.6%%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms`` tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients.</. | |
dc.language | eng | |
dc.publisher | INFORMA HEALTHCARE | |
dc.relation | Pediatric Hematology and Oncology | |
dc.rights | Copyright INFORMA HEALTHCARE | |
dc.rights | closedAccess | |
dc.subject | P-glycoprotein | |
dc.subject | prognosis | |
dc.subject | recurrence | |
dc.subject | tumor weight | |
dc.subject | Wilms` tumor | |
dc.title | P-Glycoprotein Expression, Tumor Weight, Age, and Relapse in Patients with Stage I and II Favorable-Histology Wilms` Tumor | |
dc.type | Artículos de revistas | |