Artículos de revistas
Abnormal Corpus Callosum Integrity in Bipolar Disorder: A Diffusion Tensor Imaging Study
Fecha
2008Registro en:
BIOLOGICAL PSYCHIATRY, v.64, n.8, p.730-733, 2008
0006-3223
10.1016/j.biopsych.2008.06.001
Autor
WANG, Fei
KALMAR, Jessica H.
EDMISTON, Erin
CHEPENIK, Lara G.
BHAGWAGAR, Zubin
SPENCER, Linda
PITTMAN, Brian
JACKOWSKI, Marcel
PAPACLEMETRIS, Xenophon
CONSTABLE, R. Todd
BLUMBERG, Hilary P.
Institución
Resumen
Objective: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BID). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD. Methods: Subjects included 33 participants with BID and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROD methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities. Results: In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BID group (p <.05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p <.05, corrected). Conclusion: The findings demonstrate abnormalities in the structural integrity of the anterior CC in BID that might contribute to altered interhemispheric connectivity in this disorder.