dc.creator | GOLFETO, Camilla C. | |
dc.creator | POELHSITZ, Gustavo Von | |
dc.creator | SELISTRE-DE-ARAUJO, Heloisa S. | |
dc.creator | ARAUJO, Marcio P. de | |
dc.creator | ELLENA, Javier | |
dc.creator | CASTELLANO, Eduardo Ernesto | |
dc.creator | LOPES, Luiz G. L. | |
dc.creator | MOREIRA, Icaro S. | |
dc.creator | BATISTA, Alzir A. | |
dc.date.accessioned | 2012-10-20T04:22:58Z | |
dc.date.accessioned | 2018-07-04T15:44:37Z | |
dc.date.available | 2012-10-20T04:22:58Z | |
dc.date.available | 2018-07-04T15:44:37Z | |
dc.date.created | 2012-10-20T04:22:58Z | |
dc.date.issued | 2010 | |
dc.identifier | JOURNAL OF INORGANIC BIOCHEMISTRY, v.104, n.5, p.489-495, 2010 | |
dc.identifier | 0162-0134 | |
dc.identifier | http://producao.usp.br/handle/BDPI/30133 | |
dc.identifier | 10.1016/j.jinorgbio.2009.12.015 | |
dc.identifier | http://dx.doi.org/10.1016/j.jinorgbio.2009.12.015 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1626773 | |
dc.description.abstract | The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 mu M against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized = 200 mu M). (C) 2009 Elsevier Inc. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.relation | Journal of Inorganic Biochemistry | |
dc.rights | Copyright ELSEVIER SCIENCE INC | |
dc.rights | restrictedAccess | |
dc.subject | Ruthenium | |
dc.subject | Nitrosyl | |
dc.subject | Diphosphine | |
dc.subject | Anticancer | |
dc.title | Synthesis, characterization and cytotoxic activities of the [RuCl(2)(NO)(dppp)(L)]PF(6) complexes | |
dc.type | Artículos de revistas | |