Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of insulin-like activity

dc.creatorMENDES, Isolda C.
dc.creatorBOTION, Leida M.
dc.creatorFERREIRA, Adaliene V. M.
dc.creatorCASTELLANO, Eduardo E.
dc.creatorBERALDO, Heloisa
dc.date.accessioned2012-10-20T04:21:22Z
dc.date.accessioned2018-07-04T15:43:50Z
dc.date.available2012-10-20T04:21:22Z
dc.date.available2018-07-04T15:43:50Z
dc.date.created2012-10-20T04:21:22Z
dc.date.issued2009
dc.identifierINORGANICA CHIMICA ACTA, v.362, n.2, p.414-420, 2009
dc.identifier0020-1693
dc.identifierhttp://producao.usp.br/handle/BDPI/29972
dc.identifier10.1016/j.ica.2008.04.029
dc.identifierhttp://dx.doi.org/10.1016/j.ica.2008.04.029
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1626612
dc.description.abstractReaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherELSEVIER SCIENCE SA
dc.relationInorganica Chimica Acta
dc.rightsCopyright ELSEVIER SCIENCE SA
dc.rightsrestrictedAccess
dc.subject2-Pyridineformamide thiosemicarbazones
dc.subjectVanadium
dc.subjectInsulin-like
dc.titleVanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of insulin-like activity
dc.typeArtículos de revistas


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