dc.creator | TRIBUTINO, Jorge L. M. | |
dc.creator | DUARTE, Carolina D. | |
dc.creator | CORREA, Rodrigo S. | |
dc.creator | DORIGUETTO, Antonio C. | |
dc.creator | ELLENA, Javier | |
dc.creator | ROMEIRO, Nelilma C. | |
dc.creator | CASTRO, Newton G. | |
dc.creator | MIRANDA, Ana Luisa P. | |
dc.creator | BARREIRO, Eliezer J. | |
dc.creator | FRAGA, Carlos A. M. | |
dc.date.accessioned | 2012-10-20T04:21:21Z | |
dc.date.accessioned | 2018-07-04T15:43:49Z | |
dc.date.available | 2012-10-20T04:21:21Z | |
dc.date.available | 2018-07-04T15:43:49Z | |
dc.date.created | 2012-10-20T04:21:21Z | |
dc.date.issued | 2009 | |
dc.identifier | BIOORGANIC & MEDICINAL CHEMISTRY, v.17, n.3, p.1125-1131, 2009 | |
dc.identifier | 0968-0896 | |
dc.identifier | http://producao.usp.br/handle/BDPI/29969 | |
dc.identifier | 10.1016/j.bmc.2008.12.045 | |
dc.identifier | http://dx.doi.org/10.1016/j.bmc.2008.12.045 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1626609 | |
dc.description.abstract | We described herein the molecular design of novel in vivo anti-inflammatory 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives (1) planned by applying the molecular hybridization approach. This work also points out to the discovery of LASSBio-930 (1c) as a novel anti-inflammatory and anti-hyperalgesic prototype, which was able to reduce carrageenan-induced rat paw edema with an ED(50) of 97.8 mu mol/kg, acting mainly as a non-selective COX inhibitor. (C) 2009 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.relation | Bioorganic & Medicinal Chemistry | |
dc.rights | Copyright PERGAMON-ELSEVIER SCIENCE LTD | |
dc.rights | restrictedAccess | |
dc.subject | N-Acylhydrazone derivatives | |
dc.subject | Anti-inflammatory | |
dc.subject | Anti-hyperalgesic | |
dc.subject | COX-1 inhibitor | |
dc.subject | Safrole | |
dc.subject | 1,3-Benzodioxole | |
dc.title | Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates | |
dc.type | Artículos de revistas | |