Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

dc.creatorGUIDO, Rafael Victorio Carvalho
dc.creatorBALLIANO, Tatiane L.
dc.creatorANDRICOPULO, Adriano Defini
dc.creatorOLIVA, Glaucius
dc.date.accessioned2012-10-20T04:21:11Z
dc.date.accessioned2018-07-04T15:43:45Z
dc.date.available2012-10-20T04:21:11Z
dc.date.available2018-07-04T15:43:45Z
dc.date.created2012-10-20T04:21:11Z
dc.date.issued2009
dc.identifierLETTERS IN DRUG DESIGN & DISCOVERY, v.6, n.3, p.210-214, 2009
dc.identifier1570-1808
dc.identifierhttp://producao.usp.br/handle/BDPI/29952
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000265798800008&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1626592
dc.description.abstractKinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.
dc.languageeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relationLetters in Drug Design & Discovery
dc.rightsCopyright BENTHAM SCIENCE PUBL LTD
dc.rightsrestrictedAccess
dc.subjectParasitic infections
dc.subjectTrypanosoma cruzi
dc.subjectInhibitors
dc.subjectEnzyme
dc.subjectGlyceraldehyde-3-phosphate dehydrogenase
dc.subjectX-ray crystallography
dc.titleKinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate
dc.typeArtículos de revistas


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