dc.creatorLIRA, F. S.
dc.creatorROSA, J. C.
dc.creatorYAMASHITA, A. S.
dc.creatorKOYAMA, C. H.
dc.creatorBATISTA JR., M. L.
dc.creatorSEELAENDER, M.
dc.date.accessioned2012-10-20T03:27:47Z
dc.date.accessioned2018-07-04T15:37:06Z
dc.date.available2012-10-20T03:27:47Z
dc.date.available2018-07-04T15:37:06Z
dc.date.created2012-10-20T03:27:47Z
dc.date.issued2009
dc.identifierCYTOKINE, v.45, n.2, p.80-85, 2009
dc.identifier1043-4666
dc.identifierhttp://producao.usp.br/handle/BDPI/28581
dc.identifier10.1016/j.cyto.2008.10.018
dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2008.10.018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1625224
dc.description.abstractWhite adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and recently, it has been recognized as an important source of interleukin 10 (IL-10). Acute physical exercise is known to induce an anti-inflammatory cytokine profile, however, the effect of chronic physical exercise on the production of IL-10 by WAT has never been examined. We assessed IL-10 and TNF-alpha concentration in WAT of rats engaged in endurance training. Animals were randomly assigned to either a sedentary control group (S, n = 7) or an endurance trained group (T, n = 8). Trained rats ran on a treadmill 5 days/wk for 8 wk (55-65% VO(2max). Detection of IL-10 and TNF-alpha protein and mRNA expression, as well as the gene expression of PPAR-gamma, and immunocytochemistry to detect mononuclear phagocytes were carried out. A reduction in absolute retroperitoneal adipose tissue (RPAT) weight in T (44%; p < 0.01), when compared with S was observed. IL-10 concentration was increased (1.5-fold, p < 0.05), to a higher extent than that of TNF-alpha (66%. p < 0.05) in the mesenteric adipose tissue (MEAT) of the trained group, while no change related to training was observed in RPAT. In MEAT, IL-10/TNF-alpha ratio was increased in T, when compared with S (30%; p < 0.05). PPAR-gamma gene expression was increased in T (1.1-fold; p < 0.01), when compared with S in the same adipose depot. No monocyte infiltration was found. In conclusion, exercise training induced increased IL-10 expression in the mesenteric depot, resulting in a modified IL-10/TNF-alpha ratio. We also conclude that WAT presents a depot-specific response to endurance training regarding the studied aspects. (C) 2008 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
dc.relationCytokine
dc.rightsCopyright ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectEndurance training
dc.subjectAdipose tissue
dc.subjectIL-10
dc.subjectTNF-alpha
dc.subjectPPAR-gamma
dc.titleEndurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue
dc.typeArtículos de revistas


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