dc.creator | LIRA, F. S. | |
dc.creator | ROSA, J. C. | |
dc.creator | YAMASHITA, A. S. | |
dc.creator | KOYAMA, C. H. | |
dc.creator | BATISTA JR., M. L. | |
dc.creator | SEELAENDER, M. | |
dc.date.accessioned | 2012-10-20T03:27:47Z | |
dc.date.accessioned | 2018-07-04T15:37:06Z | |
dc.date.available | 2012-10-20T03:27:47Z | |
dc.date.available | 2018-07-04T15:37:06Z | |
dc.date.created | 2012-10-20T03:27:47Z | |
dc.date.issued | 2009 | |
dc.identifier | CYTOKINE, v.45, n.2, p.80-85, 2009 | |
dc.identifier | 1043-4666 | |
dc.identifier | http://producao.usp.br/handle/BDPI/28581 | |
dc.identifier | 10.1016/j.cyto.2008.10.018 | |
dc.identifier | http://dx.doi.org/10.1016/j.cyto.2008.10.018 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1625224 | |
dc.description.abstract | White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and recently, it has been recognized as an important source of interleukin 10 (IL-10). Acute physical exercise is known to induce an anti-inflammatory cytokine profile, however, the effect of chronic physical exercise on the production of IL-10 by WAT has never been examined. We assessed IL-10 and TNF-alpha concentration in WAT of rats engaged in endurance training. Animals were randomly assigned to either a sedentary control group (S, n = 7) or an endurance trained group (T, n = 8). Trained rats ran on a treadmill 5 days/wk for 8 wk (55-65% VO(2max). Detection of IL-10 and TNF-alpha protein and mRNA expression, as well as the gene expression of PPAR-gamma, and immunocytochemistry to detect mononuclear phagocytes were carried out. A reduction in absolute retroperitoneal adipose tissue (RPAT) weight in T (44%; p < 0.01), when compared with S was observed. IL-10 concentration was increased (1.5-fold, p < 0.05), to a higher extent than that of TNF-alpha (66%. p < 0.05) in the mesenteric adipose tissue (MEAT) of the trained group, while no change related to training was observed in RPAT. In MEAT, IL-10/TNF-alpha ratio was increased in T, when compared with S (30%; p < 0.05). PPAR-gamma gene expression was increased in T (1.1-fold; p < 0.01), when compared with S in the same adipose depot. No monocyte infiltration was found. In conclusion, exercise training induced increased IL-10 expression in the mesenteric depot, resulting in a modified IL-10/TNF-alpha ratio. We also conclude that WAT presents a depot-specific response to endurance training regarding the studied aspects. (C) 2008 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD | |
dc.relation | Cytokine | |
dc.rights | Copyright ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD | |
dc.rights | restrictedAccess | |
dc.subject | Endurance training | |
dc.subject | Adipose tissue | |
dc.subject | IL-10 | |
dc.subject | TNF-alpha | |
dc.subject | PPAR-gamma | |
dc.title | Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue | |
dc.type | Artículos de revistas | |