dc.creatorJACINTHO, T. Manzoni
dc.creatorGOTHO, H.
dc.creatorGIDLUND, A.
dc.creatorMARQUES, C. Garcia
dc.creatorTORRINHAS, R.
dc.creatorSALES, Ma Mirtes
dc.creatorWAITZBERG, D. Linetzky
dc.date.accessioned2012-10-20T03:22:40Z
dc.date.accessioned2018-07-04T15:35:53Z
dc.date.available2012-10-20T03:22:40Z
dc.date.available2018-07-04T15:35:53Z
dc.date.created2012-10-20T03:22:40Z
dc.date.issued2009
dc.identifierNUTRICION HOSPITALARIA, v.24, n.3, p.288-296, 2009
dc.identifier0212-1611
dc.identifierhttp://producao.usp.br/handle/BDPI/28302
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000267402700005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1624945
dc.description.abstractBackground & aim: To compare the effect of fish oil-based (FO) lipid emulsions (LE) for parenteral administration with standard LE and a new FO containing LE composed of four different oils on the antigen presentation and inflammatory variables. Methods: Phytohemagglutinin (PHA) activated human mononuclear leukocytes were cultured with different LE - Control: without LE; SO: soybean oil; SO/FO: soybean and FO (4:1); MCT/SO: medium chain triglycerides and SO (1:1); MCT/SO/FO: MCT/SO and FO (4:1) and SMOF: a new LE containing FO. Cytokine production was evaluated by ELISA, the expression of antigen-presenting and co-stimulatory surface molecules were analyzed by flow cytometry and lymphocyte proliferation was assessed by H(3)-Thymidine incorporation, after tetanus toxoid-induced activation. Results: All LE decreased the HLA-DR and increased CD28 and CD152 expression on monocytes/macrophages and lymphocytes surface (p < 0.05). SO/FO and MCT/SO/FO decreased lymphocyte proliferation (p<0.05). All LE decreased IL-2 product ion, but this effect was enhanced with MCT/SO/FO and SMOF (p < 0.05). MCT/SOTO decreased IL-6 and increased IL-10, whereas SO had the opposite effect (p < 0.05). Conclusion: FO LE inhibited lymphocyte proliferation and had an anti-inflammatory effect. These effects seem to be enhanced when FO is mixed with MCT/SO. SMOF had a neutral impact on lymphocyte proliferation and IL-6 and IL-10 production.
dc.languageeng
dc.publisherAULA MEDICA EDICIONES
dc.relationNutricion Hospitalaria
dc.rightsCopyright AULA MEDICA EDICIONES
dc.rightsopenAccess
dc.subjectLipid emulsion
dc.subjectSoybean oil
dc.subjectFish oil
dc.subjectCo-stimulatory molecules and antigen presentation
dc.titleAnti-inflammatory effect of parenteral fish oil lipid emulsion on human activated mononuclear leukocytes
dc.typeArtículos de revistas


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