dc.creator | JACINTHO, T. Manzoni | |
dc.creator | GOTHO, H. | |
dc.creator | GIDLUND, A. | |
dc.creator | MARQUES, C. Garcia | |
dc.creator | TORRINHAS, R. | |
dc.creator | SALES, Ma Mirtes | |
dc.creator | WAITZBERG, D. Linetzky | |
dc.date.accessioned | 2012-10-20T03:22:40Z | |
dc.date.accessioned | 2018-07-04T15:35:53Z | |
dc.date.available | 2012-10-20T03:22:40Z | |
dc.date.available | 2018-07-04T15:35:53Z | |
dc.date.created | 2012-10-20T03:22:40Z | |
dc.date.issued | 2009 | |
dc.identifier | NUTRICION HOSPITALARIA, v.24, n.3, p.288-296, 2009 | |
dc.identifier | 0212-1611 | |
dc.identifier | http://producao.usp.br/handle/BDPI/28302 | |
dc.identifier | http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000267402700005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1624945 | |
dc.description.abstract | Background & aim: To compare the effect of fish oil-based (FO) lipid emulsions (LE) for parenteral administration with standard LE and a new FO containing LE composed of four different oils on the antigen presentation and inflammatory variables. Methods: Phytohemagglutinin (PHA) activated human mononuclear leukocytes were cultured with different LE - Control: without LE; SO: soybean oil; SO/FO: soybean and FO (4:1); MCT/SO: medium chain triglycerides and SO (1:1); MCT/SO/FO: MCT/SO and FO (4:1) and SMOF: a new LE containing FO. Cytokine production was evaluated by ELISA, the expression of antigen-presenting and co-stimulatory surface molecules were analyzed by flow cytometry and lymphocyte proliferation was assessed by H(3)-Thymidine incorporation, after tetanus toxoid-induced activation. Results: All LE decreased the HLA-DR and increased CD28 and CD152 expression on monocytes/macrophages and lymphocytes surface (p < 0.05). SO/FO and MCT/SO/FO decreased lymphocyte proliferation (p<0.05). All LE decreased IL-2 product ion, but this effect was enhanced with MCT/SO/FO and SMOF (p < 0.05). MCT/SOTO decreased IL-6 and increased IL-10, whereas SO had the opposite effect (p < 0.05). Conclusion: FO LE inhibited lymphocyte proliferation and had an anti-inflammatory effect. These effects seem to be enhanced when FO is mixed with MCT/SO. SMOF had a neutral impact on lymphocyte proliferation and IL-6 and IL-10 production. | |
dc.language | eng | |
dc.publisher | AULA MEDICA EDICIONES | |
dc.relation | Nutricion Hospitalaria | |
dc.rights | Copyright AULA MEDICA EDICIONES | |
dc.rights | openAccess | |
dc.subject | Lipid emulsion | |
dc.subject | Soybean oil | |
dc.subject | Fish oil | |
dc.subject | Co-stimulatory molecules and antigen presentation | |
dc.title | Anti-inflammatory effect of parenteral fish oil lipid emulsion on human activated mononuclear leukocytes | |
dc.type | Artículos de revistas | |