dc.creatorROCHA SOBRINHO, Herminio M. da
dc.creatorJARACH, Renata
dc.creatorSILVA, Nilzio A. da
dc.creatorSHIO, Marina T.
dc.creatorJANCAR, Sonia
dc.creatorTIMENETSKY, Jorge
dc.creatorOLIVEIRA, Milton A. P.
dc.creatorDORTA, Miriam L.
dc.creatorRIBEIRO-DIAS, Fatima
dc.date.accessioned2012-10-20T03:22:35Z
dc.date.accessioned2018-07-04T15:35:47Z
dc.date.available2012-10-20T03:22:35Z
dc.date.available2018-07-04T15:35:47Z
dc.date.created2012-10-20T03:22:35Z
dc.date.issued2011
dc.identifierRHEUMATOLOGY INTERNATIONAL, v.31, n.7, p.951-957, 2011
dc.identifier0172-8172
dc.identifierhttp://producao.usp.br/handle/BDPI/28287
dc.identifier10.1007/s00296-010-1612-1
dc.identifierhttp://dx.doi.org/10.1007/s00296-010-1612-1
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1624930
dc.description.abstractMycoplasmal lipid-associated membrane proteins (LAMPs) and Mycoplasma arthritidis mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of Mycoplasma hominis and M. fermentans in the sera of patients affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to identify mycoplasmal products that can be involved in the etiopathogenesis of these autoimmune diseases. Serum samples from female RA and SLE patients and controls, recombinant MAM, and LAMPs of M. hominis PG21 and M. fermentans PG18 were used in Western blot assays. A similar frequency of sera from patients and controls reactive to MAM was detected. A larger number of M. hominis and M. fermentans LAMPs were recognized by sera from RA patients than controls, but no differences were detected between sera from SLE patients and controls. Among the LAMPs recognized by IgG antibodies from RA patients, proteins of molecular masses in a range of < 49 and a parts per thousand yen20 KDa (M. hominis) and < 102 and a parts per thousand yen58 KDa (M. fermentans) were the most reactive. These preliminary results demonstrate the strong reactivity of antibodies of RA patients with some M. hominis and M. fermentans LAMPs. These LAMPs could be investigated as mycoplasmal antigens that can take part in the induction or amplification of human autoimmune responses.
dc.languageeng
dc.publisherSPRINGER HEIDELBERG
dc.relationRheumatology International
dc.rightsCopyright SPRINGER HEIDELBERG
dc.rightsrestrictedAccess
dc.subjectMycoplasmal lipoproteins
dc.subjectIgG antibodies
dc.subjectRheumatoid Arthritis
dc.subjectSystemic Lupus Erythematosus
dc.subjectSuperantigen
dc.titleMycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis
dc.typeArtículos de revistas


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