dc.creator | CHAPADOS, N. A. | |
dc.creator | SEELAENDER, M. | |
dc.creator | LEVY, E. | |
dc.creator | LAVOIE, J-M. | |
dc.date.accessioned | 2012-10-20T03:19:22Z | |
dc.date.accessioned | 2018-07-04T15:35:00Z | |
dc.date.available | 2012-10-20T03:19:22Z | |
dc.date.available | 2018-07-04T15:35:00Z | |
dc.date.created | 2012-10-20T03:19:22Z | |
dc.date.issued | 2009 | |
dc.identifier | HORMONE AND METABOLIC RESEARCH, v.41, n.4, p.287-293, 2009 | |
dc.identifier | 0018-5043 | |
dc.identifier | http://producao.usp.br/handle/BDPI/28105 | |
dc.identifier | 10.1055/s-0028-1102937 | |
dc.identifier | http://dx.doi.org/10.1055/s-0028-1102937 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1624749 | |
dc.description.abstract | Microsomal triglyceride transfer protein (MTP) is a protein that exerts a central regulatory role in very-low-density lipoprotein (VLDL) assembly and secretion. The purpose of the study was to investigate the effects of all exercise-training program oil hepatic content of MTP and its relation to hepatic VLDL-triglyceride (VLDL-TG) production in response to lipid infusion. Female rats either fed a standard (SD) or all obesity-induced high-fat (HF; 43% as energy) diet for 8 weeks were Subdivided into sedentary (Sed) and trained (Tr) groups. Exercise training consisted Of Continuous running on a motor-driven rodent treadmill 5 times/week for 8 weeks. At the end of this period, all rats in the fasted state were intravenously infused with a 20% Solution of intralipid for 3 h followed by all injection of Triton WR1339 to block lipoprotein lipase. An additional control grout) consisting of Sed rats fed the SD diet was infused with saline (0.9% NaCl). Plasma TG accumulation was thereafter measured during 90 min to estimate VLDL-TG production. Under HF diet, hepatic MTP content and plasma TG accumulation after Triton blockade (thus reflecting VLDL-TG synthesis and secretion) were not changed in Sed rats, whereas liver TG content was highly increased (similar to 90%; p<0.01). Oil the other hand, training reduced liver MTP protein content in both SD(-18%) and HF(-23%) fed rats(p<0.05). Plasma VLDL-TG accumulation was also lower (p<0.05) in Tr than in Sed rats fed the HF diet. This effect was not observed in SD fed rats. Furthermore, the exercise training-induced decrease in VLDL-TG production in HF rats was associated with a decrease in liver TG levels. It is Concluded that in addition to a reduction in liver TG content, exercise training reduces VLDL synthesis and/or secretion in HF fed rats probably via MTP regulation. | |
dc.language | eng | |
dc.publisher | GEORG THIEME VERLAG KG | |
dc.relation | Hormone and Metabolic Research | |
dc.rights | Copyright GEORG THIEME VERLAG KG | |
dc.rights | restrictedAccess | |
dc.subject | hepatic steatosis | |
dc.subject | high-fat diet | |
dc.subject | VLDL-TG production | |
dc.subject | lipid infusion | |
dc.title | Effects of Exercise Training on Hepatic Microsomal Triglyceride Transfer Protein Content in Rats | |
dc.type | Artículos de revistas | |