Artículos de revistas
Glutamine enhances glucose-induced mesangial cell proliferation
Fecha
2008Registro en:
AMINO ACIDS, v.34, n.4, p.683-685, 2008
0939-4451
10.1007/s00726-007-0002-9
Autor
LAGRANHA, Claudia J.
DOI, Sonia Q.
PITHON-CURI, Tania C.
Curi, Rui
SELLITTI, Donald F.
Institución
Resumen
The proliferation of mesangial cells (MC) in the presence of glutamine (0-20 mM) was determined in both low (5 mM) and high (25 mM) glucose-containing medium. Glutamine in a high glucose (HG) environment increased cell proliferation in a dose-dependent manner. Inhibition of glutamine:fructose 6-phosphate amidotransferase (GFAT) and of phosphodiesterase significantly reduced glutamine-induced proliferation. Supraphysiologic levels of glutamine increase MC proliferation in a HG milieu via GFAT and cAMP-dependent pathways, suggesting that glutamine could pose a risk for diabetic nephropathy.