dc.creator | MORI, R. C. T. | |
dc.creator | HIRABARA, S. M. | |
dc.creator | HIRATA, A. E. | |
dc.creator | OKAMOTO, M. M. | |
dc.creator | MACHADO, U. F. | |
dc.date.accessioned | 2012-10-20T03:17:48Z | |
dc.date.accessioned | 2018-07-04T15:34:18Z | |
dc.date.available | 2012-10-20T03:17:48Z | |
dc.date.available | 2018-07-04T15:34:18Z | |
dc.date.created | 2012-10-20T03:17:48Z | |
dc.date.issued | 2008 | |
dc.identifier | DIABETES OBESITY & METABOLISM, v.10, n.7, p.596-U5, 2008 | |
dc.identifier | 1462-8902 | |
dc.identifier | http://producao.usp.br/handle/BDPI/27950 | |
dc.identifier | 10.1111/j.1463-1326.2008.00870.x | |
dc.identifier | http://dx.doi.org/10.1111/j.1463-1326.2008.00870.x | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1624594 | |
dc.description.abstract | Aim: Glimepiride, a low-potency insulin secretagogue, is as efficient on glycaemic control as other sulphonylureas, suggesting an additional insulin-sensitizer role. The aim of the present study was to confirm the insulin-sensitizer role of glimepiride and to show extra-pancreatic effects of the drug. Methods: Three-month-old monosodium glutamate (MSG)-induced obese insulin-resistant rats were treated (OG) or not treated (O) with glimepiride for 4 weeks and compared with age-matched non-obese rats (C). Insulin sensitivity in whole body, glucose transporter 4 (GLUT4) protein content, glucose uptake and glycogen synthesis in oxidative skeletal muscle and phospho-glycogen synthase kinase (p-GSK3) and glycogen content in liver were analysed. Results: Insulin sensitivity, analysed by the insulin tolerance test, was 30% lower in O than in C rats (p < 0.05), and OG rats recovered this parameter (p < 0.05). In oxidative muscle, glimepiride increased the GLUT4 protein content (50%, p < 0.001) and recovered the obesity-induced reduction (similar to 20%) of the in vitro insulin-stimulated glucose uptake and incorporation into glycogen. In liver, glimepiride increased p-GSK3 (p < 0.01) and glycogen (p < 0.05) contents. Conclusion: The increased GLUT4 protein expression and glucose utilization in oxidative muscle and the increased insulin sensitivity and glycogen storage in liver evidence the insulin-sensitizer effect of glimepiride, which must be important to enable the glimepiride drug to promote an efficient glycaemic control. | |
dc.language | eng | |
dc.publisher | WILEY-BLACKWELL | |
dc.relation | Diabetes Obesity & Metabolism | |
dc.rights | Copyright WILEY-BLACKWELL | |
dc.rights | restrictedAccess | |
dc.subject | glimepiride | |
dc.subject | GLUT4 | |
dc.subject | insulin resistance | |
dc.subject | liver | |
dc.subject | MSG | |
dc.subject | skeletal muscle | |
dc.subject | GSK3 | |
dc.title | Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin | |
dc.type | Artículos de revistas | |