Artículos de revistas
Metabolic recovery of adipose tissue is associated with improvement in insulin resistance in a model of experimental diabetes
Fecha
2008Registro en:
JOURNAL OF ENDOCRINOLOGY, v.198, n.1, p.51-60, 2008
0022-0795
10.1677/JOE-08-0072
Autor
TAKADA, Julie
FONSECA-ALANIZ, Miriam Helena
CAMPOS, Tarcila Reatriz Ferraz de
ANDREOTTI, Sandra
CAMPANA, Amanda Baron
OKAMOTO, Maristela
BORGES-SILVA, Cristina das Neves
MACHADO, Ubiratan Fabres
LIMA, Fabio Bessa
Institución
Resumen
Obesity and insulin resistance are highly correlated with metabolic disturbances. Both the excess and lack of adipose tissue can lead to severe insulin resistance and diabetes. Adipose tissue plays an active role in energy homeostasis, hormone secretion, and other proteins that affect insulin sensitivity, appetite, energy balance, and lipid metabolism. Rats with streptozotocin-induced diabetes during the neonatal period develop the classic diabetic picture of hyperglycemia, hypoinsulinemia, and insulin resistance in adulthood. Low body weight and reduced epididymal (EP) fit mass were also seen in this model. The am) of this study was to investigate the glucose homeostasis and metabolic repercussions on the adipose tissue following chronic treatment with antidiabetic drugs in these animals. In the 4th week post birth, diabetic animals started an 8-week treatment with pioglitazone, metformin, or insulin.