dc.creatorOBICI, Simoni
dc.creatorLOPES-BERTOLINI, Gisele
dc.creatorCuri, Rui
dc.creatorBAZOTTE, Roberto Barbosa
dc.date.accessioned2012-10-20T03:17:43Z
dc.date.accessioned2018-07-04T15:34:15Z
dc.date.available2012-10-20T03:17:43Z
dc.date.available2018-07-04T15:34:15Z
dc.date.created2012-10-20T03:17:43Z
dc.date.issued2008
dc.identifierCELL BIOCHEMISTRY AND FUNCTION, v.26, n.7, p.755-759, 2008
dc.identifier0263-6484
dc.identifierhttp://producao.usp.br/handle/BDPI/27935
dc.identifier10.1002/cbf.1501
dc.identifierhttp://dx.doi.org/10.1002/cbf.1501
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1624579
dc.description.abstractThe activities of glycogen phosphorylase and synthase during infusions of glucagon, isoproterenol, or cyanide in isolated liver of fed rats submitted to short-term insulin-induced hypoglycemia (IIH) was investigated. A condition of hyperinsulinemia/hypoglycemia was obtained with an intraperitoneal injection of regular insulin (1.0 U kg(-1)). The control group received ip saline. The experiments were carried out 60 min after insulin (IIH group) or saline (COG group) injection. The rats were anesthetized and after laparotomy, blood was collected from the vena cava for glucose and insulin measurements. The liver was their infused with glucagon (1 nM), isoproterenot (2 mu M), or cyanide (0.5 mM) during 20 min and a sample of the organ was collected for determination of the activities of glycogen phosphorylase and synthase 5 min after starting and 10 min after stopping the infusions. The infusions of cyanide, glucagons, and isoproterenol did not change the activities of glycogen synthase and glycogen phosphorylase. However, glycogen catabolism was decreased during the infusions of glucagon and isoproterenol in IIH rats, being more intense with isoproterenol (p < 0.05), than glucagon. It was concluded that short-term IIH promoted changes in the liver responsiveness of glycogen degradation induced by glucagon and isoproterenol without a change in the activities of glycogen phosphorylase and synthase. Copyright (c) 2008 John Wiley & Sons, Ltd.
dc.languageeng
dc.publisherJOHN WILEY & SONS LTD
dc.relationCell Biochemistry and Function
dc.rightsCopyright JOHN WILEY & SONS LTD
dc.rightsrestrictedAccess
dc.subjectglycogen phosphorylase
dc.subjectglycogen synthase
dc.subjectglucagon
dc.subjectisoproterenol
dc.subjectglycolysis
dc.subjectglycogenolysis
dc.titleLiver glycogen metabolism during short-term insulin-induced hypoglycemia in fed rats
dc.typeArtículos de revistas


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